GLRB
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| Location (UCSC) | Chr 4: 157.08 – 157.17 Mb | Chr 3: 80.75 – 80.82 Mb | |||||||
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Glycine receptor subunit beta is a protein that in humans is encoded by the GLRB gene.[5][6][7]
The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha (GLRA1, MIM 138491; GLRA2, MIM 305990) and beta subunits.[supplied by OMIM][7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000109738 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028020 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9676428.
- PMID 8717357.
- ^ a b "Entrez Gene: GLRB glycine receptor, beta".
Further reading
- Meyer G, Kirsch J, Betz H, Langosch D (1995). "Identification of a gephyrin binding motif on the glycine receptor beta subunit". Neuron. 15 (3): 563–72. S2CID 10164739.
- Sarang SS, Miller GW, Grant DF, Schnellmann RG (1999). "Expression and localization of the neuronal glycine receptor beta-subunit in human, rabbit and rat kidneys". Nephron. 82 (3): 254–60. S2CID 382638.
- Rees MI, Lewis TM, Kwok JB, et al. (2002). "Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB)". Hum. Mol. Genet. 11 (7): 853–60. PMID 11929858.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Chen Z, Dillon GH, Huang R (2004). "Molecular determinants of proton modulation of glycine receptors". J. Biol. Chem. 279 (2): 876–83. PMID 14563849.
- Burzomato V, Groot-Kormelink PJ, Sivilotti LG, Beato M (2004). "Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation". Recept. Channels. 9 (6): 353–61. PMID 14698963.
- Harvey K, Duguid IC, Alldred MJ, et al. (2004). "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering" (PDF). J. Neurosci. 24 (25): 5816–26. PMID 15215304.
- Grudzinska J, Schemm R, Haeger S, et al. (2005). "The beta subunit determines the ligand binding properties of synaptic glycine receptors". Neuron. 45 (5): 727–39. S2CID 2778607.
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External links
- GLRB+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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