Large-cell lymphoma

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "Large-cell lymphoma" – news · newspapers · books · scholar · JSTOR (October 2021) (Learn how and when to remove this message)

The large-cell lymphomas have large cells. One classification system for

Diffuse large B-cell lymphoma is the most common of the large-cell lymphomas. MeSH now classifies the phrase "large-cell lymphoma" under "Diffuse large B cell lymphoma".^[2]

Many other B-cell lymphomas feature large cells:^{[citation needed]}

• Angiocentric lymphoma
• Burkitt's lymphoma
• Follicular large-cell lymphoma
• Immunoblastic lymphoma
• Intravascular large-cell lymphoma
• Primary mediastinal B-cell lymphoma
• T-cell–rich B-cell lymphoma
• Primary splenic lymphoma (rare)
• Primary central nervous system lymphomas, which are often diffuse large-B-cell lymphomas
• Richter's transformation: Diffuse Large B-cell Variant
• 1) ABC subtype (common)
• 2) GCB subtype (rare)

Activated B-Cell Diffuse Large B-Cell Lymphoma, or ABC-DLBCL, is believed to be caused by aberrant activation of a critical intracellular pathway. This intracellular signaling pathway involved in B-cell activation and proliferation stays constantly activated, driving lymphocytes to proliferate continuously. The inhibition of this pathway can be induced by a drug known as NEMO Binding Domain, or NBD, a peptide causing increased cell death of malignant lymphocytes.^{[citation needed]}

T cell

Less commonly, a large-cell lymphoma may feature