Lewis Tilney
Lewis Tilney | |
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Nationality | U.S. |
Alma mater |
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Awards |
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Scientific career | |
Fields | Cell Biology |
Institutions |
Lewis G. Tilney is an American
Research and publications
Research interests
Tilney's research interests and primary research focus has been on the
Drosophila
Tilney’s research in Drosophila focused on the actin filaments. He observed the cross-linking of adjacent filaments and using forked proteins and fascin investigated how the bundles formed.[4] He observed that in mutants, the aggregation of bundles did not occur which resulted in significantly smaller bundle sizes compared to the wild type. From this, he performed experiments using and removing cross-linking agents forked proteins and fascin to investigate each cross-linkers role in properly forming actin bundles. From his work, he reached the conclusions that forked proteins are used early in the process to aggregate smaller bundles into large ones and they also help the bundles come together. Forked proteins also help fascin entry into the bundles which allows the bundles to cross-link and align properly.[5] He conducted further experiments using antibodies specific to fascin and the forked proteins to show when they were present in actin formation. From this research, he was able to identify that fascin was present predominantly during bundle elongation whereas the forked proteins were present during bundle formation and consequently played a significant role in the shape and size of the actin bundles. Further, it was demonstrated the amount of actin polymerization was also limited by the area where actin had the ability to adhere to connector material.[6]
Toxoplasma gondii
Tilney also conducted research focused on
Awards and honors
Tilney was elected into the
References
- ^ "Lewis Tilney | Department Of Biology". Live-Sas-Bio.Pantheon.Sas.Upenn.Edu, 2020, https://live-sas-bio.pantheon.sas.upenn.edu/people/lewis-tilney .
- ^ "Faculty | Biomedical Graduate Studies | Perelman School Of Medicine At The University Of Pennsylvania". Med.Upenn.Edu, 2020, https://www.med.upenn.edu/apps/ faculty/index.php/g20000320/p4380899
- ^ a b "Lewis Tilney". Nasonline.Org, 2020, http://www.nasonline.org/member-directory/m embers/3005869.html.
- PMID 9763425.
- ^ Tilney, L G et al. "Actin Filaments And Microtubules Play Different Roles During Bristle Elongation In Drosophila". Journal Of Cell Science, vol 113, no. 7, 2000, pp. 1255-1265.
- PMID 10629220.
- PMID 10430901.
- PMID 11880042.
- ^ "John Simon Guggenheim Foundation | About The Fellowship". Gf.Org, 2020, https://www.gf.org/about/fellowship/ .