Losartan/hydrochlorothiazide

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Losartan/hydrochlorothiazide
Combination of
Thiazide diuretic
Clinical data
Trade namesHyzaar, Cozaar comp, others
AHFS/Drugs.comProfessional Drug Facts
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
KEGG
CompTox Dashboard (EPA)

Losartan/hydrochlorothiazide, sold under the brand name Hyzaar among others, is a

by mouth.[1][2]

Common side effects include dizziness, back pain, and upper respiratory tract infections.

angiotensin II while hydrochlorothiazide works by decreasing the ability of the kidneys to absorb electrolytes.[1]

The combination was approved for medical use in the United States in 1995.

generic medication.[2] In 2021, it was the 87th most commonly prescribed medication in the United States, with more than 8 million prescriptions.[4][5]

Medical uses

The combination is

indicated for the treatment of hypertension, to lower blood pressure;[1] and for the reduction of the risk of stroke in people with hypertension and left ventricular hypertrophy.[1]

Side Effects

Common side effects include dizziness, headache, back pain, rash, fever, diarrhea, cough, and upper respiratory tract infections.

electrolyte problems.[1]

Drug interactions

Drug interactions include lithium, agents increasing serum levels of potassium, nonsteroidal anti-inflammatory drugs (NSAIDs), antidiabetic drugs, cholestyramine, and colestipol.[1]

Mechanisms

Losartan works by blocking the effects of

angiotensin II by preventing it from binding to the angiotensin I receptor while hydrochlorothiazide works by decreasing the ability of the kidneys to absorb electrolytes. The effects of hydrochlorothiazide indirectly lower the levels of serum potassium. However, with coadministration of losartan which is an angiotensin II receptor antagonist, the low levels of potassium are reversed.[1]

Society and culture

Brand names

The losartan/hydrochlorothiazide combination preparation is marketed by Merck under the brand name Hyzaar and by Xeno Pharmaceuticals under the name Anzaplus.[6] Merck, Sharp & Dohme market it as Ocsaar Plus in Israel. It is marketed as Cozaar comp in Sweden and South Africa.

References

  1. ^ a b c d e f g h i j k l m n "Hyzaar- losartan potassium and hydrochlorothiazide tablet, film coated". DailyMed. Retrieved 31 March 2021.
  2. ^
    ISBN 9780857113382
    .
  3. ^ "Hydrochlorothiazide / losartan Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
  4. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  5. ^ "Hydrochlorothiazide; Losartan - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
  6. ^ "Losartan And Hydrochlorothiazide (Oral Route) Description and Brand Names - Mayo Clinic". www.mayoclinic.org. Retrieved 5 April 2024.


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