Zofenopril

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Zofenopril
Clinical data
Trade namesZocardis (RU)
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
Identifiers
  • (2S,4S)-1-[(2S)-3-benzoylsulfanyl-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic acid
JSmol)
  • O=C(N2[C@H](C(=O)O)C[C@H](Sc1ccccc1)C2)[C@H](C)CSC(=O)c3ccccc3
  • InChI=1S/C22H23NO4S2/c1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17/h2-11,15,18-19H,12-14H2,1H3,(H,25,26)/t15-,18+,19+/m1/s1 ☒N
  • Key:IAIDUHCBNLFXEF-MNEFBYGVSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Zofenopril (

medication that protects the heart and helps reduce high blood pressure. It is an angiotensin-converting enzyme (ACE) inhibitor.[1]

In small studies, zofenopril appeared significantly more effective in reducing hypertension than two older antihypertensive drugs, atenolol and enalapril, and was associated with fewer adverse effects.[2][3]

Zofenopril is a prodrug with zofenoprilat as the active metabolite.[4]

It was patented in 1978 and approved for medical use in 2000.[5]

References

  1. S2CID 41320204
    .
  2. S2CID 22145457
    .
  3. S2CID 27469549
    .
  4. doi:10.1111/j.1527-3466.1999.tb00008.x
    .
  5. ISBN 978-3-527-60749-5
    .
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