Losartan

Source: Wikipedia, the free encyclopedia.

Losartan
Skeletal formula
Ball-and-stick model
Clinical data
Pronunciation/loʊˈsɑːrtən/
Trade namesCozaar, others
AHFS/Drugs.comMonograph
MedlinePlusa695008
License data
Pregnancy
category
Angiotensin II receptor antagonist
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability25–35%
Protein binding99.7% (primarily albumin)
MetabolismLiver (CYP2C9, CYP3A4)
Elimination half-life1.5–2 hours
ExcretionKidney 13–25%, bile duct 50–60%
Identifiers
  • (2-butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
JSmol)
  • CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
  • InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28) checkY
  • Key:PSIFNNKUMBGKDQ-UHFFFAOYSA-N checkY
  (verify)

Losartan, sold under the brand name Cozaar among others, is a

blood pressure medication.[4] Up to six weeks may be required for the full effects to occur.[4]

Common adverse effects include muscle cramps, stuffy nose, dizziness, cough,

angiotensin II.[4]

Losartan was patented in 1986, and approved for medical use in the United States in 1995.

generic medication.[7] In 2021, it was the eighth most commonly prescribed medication in the United States, with more than 55 million prescriptions.[8][9] A version combined with hydrochlorothiazide is available[4] which, in 2021, was the 87th most commonly prescribed medication in the United States, with more than 8 million prescriptions.[8][10]

Chemistry

Losartan potassium is chemically described as 2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt. Its empirical formula is C22H23CIKN6O , and its molecular weight is 422.9.[11]

Losartan is generally marketed as the (basic) potassium salt of the aromatized negatively charged tetrazole, called "losartan potassium".[12] The molecule has an extended biphenyl group with a tetrazole which is being used in place of the carboxylic acid as a bioisostere.[13]

Medical uses

Losartan is used for hypertension, including in people with left ventricular hypertrophy (enlarged heart muscle), and kidney dysfunction among type II diabetics.[3] It may also delay progression of diabetic nephropathy. It is a suitable pharmacological agent for the reduction of renal disease progression in patients with type 2 diabetes, hypertension, and microalbuminuria (>30 mg/24 hours) or proteinuria (>900 mg/24 hours).[14]

Although evidence shows

thiazide-type diuretics are preferred first-line treatments for most people (due to both efficacy and cost), an angiotensin II receptor antagonist such as losartan is recommended as first-line treatment in people under the age of 55 who cannot tolerate an ACE inhibitor.[15] One study demonstrated losartan was superior to atenolol in the primary prevention of adverse cardiovascular events (myocardial infarction or stroke), with a reduction in cardiovascular morbidity and mortality for a comparable reduction in blood pressure. The maximal effects on blood pressure usually occur within 3–6 weeks of starting losartan.[16]

Adverse effects

The most common adverse effects for losartan in adults are upper

allergic reaction.[3] Losartan should not be taken by people who are diabetic and taking aliskiren.[3] Anemia may occur, due to inhibition of the renin–angiotensin system.[17] As with other angiotensin receptor blockers, losartan may injure the liver, although this effect appears to be rare.[18] Electrolyte imbalances may occur in people with kidney problems who take losartan.[3] Adverse outcomes do not differ by sex, age or race.[3]

Pregnancy

In October 2014, the U.S. Food and Drug Administration (FDA) issued a black box warning that losartan can cause fetal toxicity, and should be discontinued as soon as pregnancy is detected.[19][3] Using losartan while pregnant could result in fetal injury or death.[19][3]

Overdose

Overdosing would most likely result in decreased blood pressure, which could manifest as an increased heart rate, dizziness, feeling light headed, or loss of consciousness. Mice studies showed that lethality occurred at about 44 to 170 times the maximum recommended dose after the mice weights were taken into account.[3]

Interactions

Losartan may have adverse

rifampin, or fluconazole, possibly inhibiting its blood pressure-lowering effects.[3]

Contamination

See also: Valsartan § recalls, and Angiotensin II receptor blocker § recalls

Between November 2018 and September 2019, the FDA announced multiple recalls of tablets containing losartan by

N-nitrosodiethylamine, N-methylnitrosobutyric acid, or N-nitroso-N-methyl-4-aminobutyric acid in the active pharmaceutical ingredient (API).[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]

Mechanism of action

Renin-angiotensin-aldosterone system (RAAS)

Losartan is a selective, competitive angiotensin II receptor type 1 (AT1) antagonist, reducing the end organ responses to angiotensin II. Losartan administration results in a decrease in total peripheral resistance (afterload) and cardiac venous return (preload). All of the physiological effects of angiotensin II, including release of aldosterone, are antagonized in the presence of losartan. Reduction in blood pressure occurs independently of the status of the renin–angiotensin system. As a result of losartan dosing, plasma renin activity increases due to removal of the angiotensin II feedback. Renin is released from the kidneys when there is reduced renal arterial pressure, sympathetic activation, or increased sodium delivery to the distal renal tubule.[38] Renin then acts by converting angiotensinogen to angiotensin I; angiotensin converting enzyme (ACE) converts angiotensin I to angiotensin II; angiotensin II causes vasoconstriction and aldosterone release.[38] Aldosterone serves to retain sodium from the distal renal tubule. Sodium retention ultimately results in increased blood pressure.[39] Therefore, the use of angiotensin II receptor antagonists like losartan result in blocking the downstream effect of renin, angiotensin II, and ultimately decreasing blood pressure.

Angiotensin II receptor antagonists include losartan,

ACE inhibitors, such as lisinopril, because there are other enzymes than ACE that have the capability of producing angiotensin II.[38]

Losartan is a uricosuric. As a specific inhibitor of the urate transporter 1 (SLC22A12, URAT1), losartan blocks the uptake of uric acid into cells, thus leaving more available in the bloodstream to be filtered and excreted by the kidneys.[40] Because losartan can cause hyperkalemia, individuals should not use potassium supplements or salt substitutes containing potassium without appropriate monitoring by a physician.[41]

Pharmacokinetics

Losartan is well absorbed following oral administration and undergoes significant first-pass metabolism to produce the 5-carboxylic acid metabolite, designated as EXP3174. About 14% of an oral dosage is converted to this metabolite, which is long-acting (6 to 8 hr) and a noncompetitive antagonist at the AT1 receptor, contributing to the pharmacological effects of losartan. EXP3174 is 10-40 times more potent in blocking AT1 receptors than losartan. In addition, the binding to the target enzyme is pH-sensitive, and the negatively-charged tetrazole ring, which is similar in size to the negative carboxylic acid derivative, may contribute to the activity of the drug.[42]

Losartan's bioavailability is about 33%.[43]

Metabolism is primarily by

isoenzymes CYP2C9 and CYP3A4.[44] Peak plasma concentrations of losartan and EXP3174 occur about one hour and three to four hours, respectively, after an oral dose.[45] Both losartan and EXP3174 are more than 98% bound to plasma proteins.[46] Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites.[47] About 4% of an oral dose is excreted unchanged in urine, and about 6% is excreted in urine as the active metabolite.[48] The terminal elimination half lives of losartan and EXP3174 are about 1.5 to 2.5 hours and 3 to 9 hours, respectively.[49]

Losartan and other angiotensin-receptor antagonists exhibit fetal toxicity and should be avoided during pregnancy, particularly in the second and third trimesters.[50]

History

Main article: Discovery and development of angiotensin receptor blockers

References

  1. ^ a b c "Losartan (Cozaar) Use During Pregnancy". Drugs.com. Archived from the original on 10 December 2017. Retrieved 10 December 2017.
  2. FDA
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  3. ^ a b c d e f g h i j k "Cozaar- losartan potassium tablet, film coated". DailyMed. 14 November 2019. Archived from the original on 28 April 2021. Retrieved 20 March 2020.
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  13. ^ "DailyMed - Losartan Potassium 25 mg- losartan potassium tablet, film coated ; Losartan Potassium 50 mg- losartan potassium tablet, film coated ; Losartan Potassium 100 mg- losartan potassium tablet, film coated". Archived from the original on 27 April 2022. Retrieved 27 April 2022.
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  20. ^ "FDA provides update on its ongoing investigation into ARB drug products; reports on finding of a new nitrosamine impurity in certain lots of losartan and product recall" (Press release). U.S. Food and Drug Administration (FDA). 3 October 2019. Archived from the original on 3 October 2019. Retrieved 3 October 2019.
  21. ^ "Sandoz Inc. Issues Voluntary Nationwide Recall of One Lot of Losartan Potassium and Hydrochlorothiazide Due to the Detection of Trace Amounts of NDEA (N-Nitrosodiethylamine) Impurity Found in the Active Pharmaceutical Ingredient (API)". U.S. Food and Drug Administration (FDA). 8 November 2018. Archived from the original on 7 September 2019. Retrieved 5 October 2019.
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  24. ^ "UPDATED: Torrent Pharmaceuticals Limited Issues Voluntary Nationwide Recall of Losartan Potassium Tablets, USP and Losartan Potassium and Hydrochlorothiazide Tablets, USP". U.S. Food and Drug Administration (FDA). 22 January 2019. Archived from the original on 7 September 2019. Retrieved 5 October 2019.
  25. ^ "Updated: Torrent Pharmaceuticals Limited Issues Voluntary Nationwide Recall of Losartan Potassium Tablets, USP and Losartan Potassium /Hydrochlorothiazide Tablets, USP". U.S. Food and Drug Administration (FDA). 1 March 2019. Archived from the original on 7 September 2019. Retrieved 5 October 2019.
  26. ^ "Updated: Torrent Pharmaceuticals Limited Expands Voluntary Nationwide Recall of Losartan Potassium Tablets, USP and Losartan Potassium/Hydrochlorothiazide Tablets, USP". U.S. Food and Drug Administration (FDA). 18 April 2019. Archived from the original on 6 October 2019. Retrieved 5 October 2019.
  27. ^ "Updated: Torrent Pharmaceuticals Limited Expands Voluntary Nationwide Recall of Losartan Potassium Tablets, USP and Losartan Potassium / Hydrochlorothiazide Tablets, USP". U.S. Food and Drug Administration (FDA). 23 September 2019. Archived from the original on 6 October 2019. Retrieved 23 September 2019.
  28. ^ "Legacy Pharmaceutical Packaging, LLC Expands Voluntary Nationwide Recall of Losartan Potassium Tablets, USP, 50mg Due to the Detection of Trace Amounts of N-Nitroso N-Methyl 4-amino butyric acid (NMBA) Impurity Found in the Active Pharmaceutical Ingredient (API)". U.S. Food and Drug Administration (FDA). 15 July 2019. Archived from the original on 13 September 2019. Retrieved 5 October 2019.
  29. ^ "Macleods Pharmaceutical Limited Issues Voluntary Nationwide Consumer Level Recall of Losartan Potassium 50mg and Losartan Potassium/Hydrochlorothiazide combination Tablets 50mg/12.5mg, 100mg/12.5mg and 100mg/25mg due to detection of NMBA (N-Nitroso-N-Methyl-4-aminobutyric acid) Impurity". U.S. Food and Drug Administration (FDA). 26 June 2019. Archived from the original on 1 October 2019. Retrieved 5 October 2019.
  30. ^ "Teva Pharmaceuticals USA, Inc. Expands Voluntary Nationwide Recall of Losartan Potassium to 50 mg and 100 mg Tablets USP, Sold Exclusively to Golden State Medical Supply, Inc". U.S. Food and Drug Administration (FDA). 11 June 2019. Archived from the original on 13 September 2019. Retrieved 5 October 2019.
  31. ^ "Vivimed Life Sciences Pvt Ltd Issues Voluntary Nationwide Recall of Losartan Potassium 25 mg, 50 mg and 100 mg Tablets, USP Due to the Detection of Trace Amounts of N-Nitroso-N-methyl-4-aminobutyric acid (NMBA) Impurity". U.S. Food and Drug Administration (FDA). 3 May 2019. Archived from the original on 13 September 2019. Retrieved 5 October 2019.
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  33. ^ "Legacy Pharmaceutical Packaging, LLC Issues Voluntary Nationwide Recall of Losartan Potassium Tablets, USP, 25mg, 50mg, And 100mg Due to The Detection of Trace Amounts Of N-Nitroso N-Methyl 4-Amino Butyric Acid (NMBA) Impurity Found in The Active Pharmaceutical Ingredient (API)". U.S. Food and Drug Administration (FDA). 19 March 2019. Archived from the original on 7 September 2019. Retrieved 5 October 2019.
  34. ^ "Legacy Pharmaceutical Packaging, LLC Issues Voluntary Nationwide Recall of Losartan Potassium Tablets, USP, 25mg, 50mg, and 100mg Due to the Detection of Trace Amounts of N-Nitroso N-Methyl 4-Amino Butyric Acid (NMBA) Impurity Found in the Active Pharmaceutical Ingredient (API)". U.S. Food and Drug Administration (FDA). 28 March 2019. Archived from the original on 7 September 2019. Retrieved 5 October 2019.
  35. ^ "Legacy Pharmaceutical Packaging, LLC Issues Voluntary Nationwide Recall of Losartan Potassium Tablets, USP, 50mg Due to the Detection of Trace Amounts of N-Nitroso N-Methyl 4-amino butyric acid (NMBA) Impurity found in the Active Pharmaceutical Ingredient (API)". U.S. Food and Drug Administration (FDA). 15 March 2019. Archived from the original on 7 September 2019. Retrieved 5 October 2019.
  36. ^ "Camber Pharmaceuticals, Inc. Issues Voluntary Nationwide Recall of Losartan Potassium Tablets, USP, 25 mg, 50 mg and 100 mg Due to the Detection of Trace Amounts of N-Nitroso N-Methyl 4-amino butyric acid (NMBA) Impurity found in the Active Pharmaceutical Ingredient (API)". U.S. Food and Drug Administration (FDA). 28 February 2019. Archived from the original on 7 September 2019. Retrieved 5 October 2019.
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  45. ^ "DailyMed - LOSARTAN POTASSIUM 25 MG- losartan potassium tablet, film coated LOSARTAN POTASSIUM 50 MG- losartan potassium tablet, film coated LOSARTAN POTASSIUM 100 MG- losartan potassium tablet, film coated". Archived from the original on 27 April 2022. Retrieved 27 April 2022.
  46. ^ "DailyMed - LOSARTAN POTASSIUM 25 MG- losartan potassium tablet, film coated LOSARTAN POTASSIUM 50 MG- losartan potassium tablet, film coated LOSARTAN POTASSIUM 100 MG- losartan potassium tablet, film coated". Archived from the original on 27 April 2022. Retrieved 27 April 2022.
  47. ^ "DailyMed - LOSARTAN POTASSIUM 25 MG- losartan potassium tablet, film coated LOSARTAN POTASSIUM 50 MG- losartan potassium tablet, film coated LOSARTAN POTASSIUM 100 MG- losartan potassium tablet, film coated". Archived from the original on 27 April 2022. Retrieved 27 April 2022.
  48. ^ "DailyMed - LOSARTAN POTASSIUM 25 MG- losartan potassium tablet, film coated LOSARTAN POTASSIUM 50 MG- losartan potassium tablet, film coated LOSARTAN POTASSIUM 100 MG- losartan potassium tablet, film coated". Archived from the original on 27 April 2022. Retrieved 27 April 2022.
  49. ^ "DailyMed - LOSARTAN POTASSIUM 25 MG- losartan potassium tablet, film coated LOSARTAN POTASSIUM 50 MG- losartan potassium tablet, film coated LOSARTAN POTASSIUM 100 MG- losartan potassium tablet, film coated". Archived from the original on 27 April 2022. Retrieved 27 April 2022.
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Further reading

External links
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