Trabecular meshwork

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "Trabecular meshwork" – news · newspapers · books · scholar · JSTOR (December 2008) (Learn how and when to remove this template message)

Trabecular meshwork
Enlarged general view of the iridial angle. (When enlarged, visible with older label of 'trabecular tissue')
Details
Identifiers
Latin	reticulum trabeculare sclerae
MeSH	D014129
Anatomical terminology [edit on Wikidata]

The trabecular meshwork is an area of tissue in the

The tissue is spongy and lined by trabeculocytes; it allows fluid to drain into a set of tubes called Schlemm's canal which is lined by endothelium with blood and lymphatic properties that allow aqueous humor to flow into the blood system.^[1]

Structure

The meshwork is divided up into three parts, with characteristically different ultrastructures:

1. Inner uveal meshwork - Closest to the anterior chamber angle, contains thin cord-like trabeculae, orientated predominantly in a radial fashion, enclosing trabeculae spaces larger than the corneoscleral meshwork.
2. Corneoscleral meshwork - Contains a large amount of elastin, arranged as a series of thin, flat, perforated sheets arranged in a laminar pattern; considered the ciliary muscle tendon.^[2]
3. Juxtacanalicular tissue (also known as the cribriform meshwork) - Lies immediately adjacent to Schlemm's canal, composed of connective tissue
   glycoproteins
   . This thin strip of tissue is covered by a monolayer of endothelial cells.

The trabecular meshwork is assisted to a small degree in the drainage of aqueous humour by a second outflow pathway, the uveo-scleral pathway (5-10% of outflow occurs this way). The uveo-scleral pathway is increased with the use of

The trabecular meshwork had previously been thought to arise from a point (apex) corresponding to the termination of the DM (Schwalbe's line) however it is now considered to extend into the cornea, forming the Dua's layer.^[3]

Clinical significance

Glaucoma

It is thought that most cases of glaucoma (although not all) are caused or enabled by an increase in intraocular pressure. Pressure increases either when too much aqueous humor fluid is produced or by decreased aqueous humor outflow. The trabecular meshwork is responsible for most of the outflow of aqueous humor. When outflow is blocked, interventions such as trabeculectomy, trabeculoplasty, or aqueous shunt may be required to restore it.

See also

• Ocular hypertension

References