Tumor-associated glycoprotein 72
kDa.[7]
TAG-72 is a
gastric cancer
, with a correlation to the neoplasia's extension. It is used to identify relapses of the disease and to follow up the treatment.
TAG-72 is also the target of the anti-cancer drugs anatumomab mafenatox and minretumomab.
References
- ^ Ponnusamy MP, Venkatraman G, Singh AP, Chauhan SC, Johansson SL, Jain M, Smith L, Davis JS, Remmenga SW, Batra SK. Expression of TAG-72 in ovarian cancer and its correlation with tumor stage and patient prognosis. Cancer Lett. 2007 Jun 28;251(2):247-57. doi: 10.1016/j.canlet.2006.11.025. Epub 2007 Jan 8. PMID: 17210225.
- ^ Murad JP, Kozlowska AK, Lee HJ, Ramamurthy M, Chang WC, Yazaki P, Colcher D, Shively J, Cristea M, Forman SJ, Priceman SJ. Effective Targeting of TAG72+ Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells. Front Immunol. 2018 Nov 19;9:2268. doi: 10.3389/fimmu.2018.02268. PMID: 30510550; PMCID: PMC6254427.
- ^ Shu R, Evtimov VJ, Hammett MV, Nguyen NN, Zhuang J, Hudson PJ, Howard MC, Pupovac A, Trounson AO, Boyd RL. Engineered CAR-T cells targeting TAG-72 and CD47 in ovarian cancer. Mol Ther Oncolytics. 2021 Jan 16;20:325-341. doi: 10.1016/j.omto.2021.01.002. PMID: 33614914; PMCID: PMC7868933.
- ^ Hege KM, Bergsland EK, Fisher GA, Nemunaitis JJ, Warren RS, McArthur JG, Lin AA, Schlom J, June CH, Sherwin SA. Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer. J Immunother Cancer. 2017 Mar 21;5:22. doi: 10.1186/s40425-017-0222-9. PMID: 28344808; PMCID: PMC5360066.
- ^ TAG-72 antigen entry in the public domain NCI Dictionary of Cancer Terms
- S2CID 205469234.
- PMID 3180090.
- S2CID 25798287.
- PMID 12237895.
- S2CID 24698852.
- PMID 12118264.
- PMID 8912871.
This article incorporates
U.S. National Cancer Institute
.
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