CA19-9

Sialyl-Lewis^A

Names
Systematic IUPAC name (12S,14S,15R,16R,32R,33R,34S,35S,36R,52R,53S,54R,55R,56Ξ,72S,73S,74R,75S,76S)-15,55-Diacetamido-14,33,35,56,73,74,75-heptahydroxy-36,52-bis(hydroxymethyl)-76-methyl-16-[(1R,2R)-1,2,3-trihydroxypropyl]-2,4,6-trioxa-1,7(2),3(4,2),5(4,3)-tetraoxanaheptaphane-12-carboxylic acid
Other names sialyl LeA, SLeA, cancer antigen 19-9, CA19-9
Identifiers
CAS Number	92448-22-1 Y
3D model ( JSmol )	Interactive image
ChEBI	CHEBI:61793
ChemSpider	9160877
MeSH	sialyl+Lewis+A
PubChem CID	10985677
UNII	ZEJ6FM4UJK Y
SMILES O=C(O)[C@@]1(O[C@H]2[C@@H](O)[C@@H](CO)O[C@@H](O[C@H]3[C@H](O[C@H]4[C@@H](O)[C@H](O)[C@H](O)[C@H](C)O4)[C@@H](CO)OC(O)[C@@H]3NC(C)=O)[C@@H]2O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O1
Properties
Chemical formula	C31H52N2O23
Molar mass	820.748 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is YN ?) Infobox references

Carbohydrate antigen 19-9 (CA19-9), also known as sialyl-Lewis^A, is a tetrasaccharide which is usually attached to O-glycans on the surface of cells. It is known to play a role in cell-to-cell recognition processes. It is also a tumor marker used primarily in the management of pancreatic cancer.^[1]

Structure

CA19-9 is the sialylated form of Lewis Antigen^A. It is a tetrasaccharide with the sequence Neu5Acα2-3Galβ1-3[Fucα1-4]GlcNAcβ.

Clinical significance

Tumor marker

Guidelines from the

CA19-9 can be elevated in many types of gastrointestinal cancer, such as colorectal cancer, esophageal cancer and hepatocellular carcinoma.^[1] Apart from cancer, elevated levels may occur in pancreatitis, cirrhosis,^[1] and diseases of the bile ducts.^[1][3] It can also be elevated in people with obstruction of the bile ducts.^[3]

In patients who lack the

• Sialyl-Lewis X
• Lewis antigen system

References