Vincent Racaniello
Vincent R. Racaniello | |
---|---|
MIT (Post-doctoral) | |
Known for | CD155 (poliovirus receptor, PVR) |
Scientific career | |
Fields | Microbiology Immunology Virology |
Institutions | Columbia University College of Physicians & Surgeons |
Vincent R. Racaniello (born January 2, 1953) is a Higgins Professor in the Department of Microbiology and Immunology at Columbia University's College of Physicians and Surgeons.[1] He is a co-author of a textbook on virology, Principles of Virology.[2][3]
Racaniello has received the Irma T. Hirschl,
Racaniello is the host of various podcasts, including This Week in Virology.
Early life and education
Racaniello was born in
Research
Racaniello established his own research laboratory at Columbia University in the fall of 1982.[10] The aim of his laboratory is to understand replication and pathogenesis of small RNA animal viruses,
Humans are the only known natural host for poliovirus. The study of viral disease is therefore only feasible with the generation of a small animal model. Though not susceptible to poliovirus infection, murine cells do allow for efficient replication of poliovirus RNA introduced into the cytoplasm. Taking advantage of this observation, Racaniello's laboratory constructed the first small animal model of
Poliomyelitis is a disease of the central nervous system; however, it is believed that CD155 is present on the surface of most if not all cells of the body. An element present within the virus RNA was hypothesized to govern viral tropism which tissues the virus infected. Newborn mice producing PVR were infected with wild-type poliovirus and a chimeric poliovirus in which this element was replaced with the same region from hepatitis C virus, a liver specific virus, or coxsackievirus B3, a virus that infects the heart or meninges. Mice infected with any of these viruses exhibited symptoms of poliomyelitis. Therefore, this region of poliovirus does not determine tissue tropism of the virus.[16]
Secretion of interferon is one means the body uses to ward off pathogens, including viral diseases. However, poliovirus is able to replicate when interferon is added to medium used to culture mammalian cells. Racaniello's laboratory believes that this resistance is dictated by the 2A protein of poliovirus.[17][18] Racaniello's laboratory continues to investigate how poliovirus circumvents the immune response of the host, enhancing our understanding of its pathogenesis and why it is a disease of the central nervous system.
Research after poliovirus
Even though global eradication of poliovirus was initiated in 1988, and poliovirus infection continues throughout the world today, Racaniello's laboratory has begun to investigate the reproductive cycle and pathogenesis of other picornaviruses similar to poliovirus. These viruses include
Racaniello is also interested in picornavirus evolution and movement. To this means, he intends to isolate and identify picornaviruses found in the wild throughout the Northeastern United States.
Racaniello's laboratory continues to pursue the fundamental principles of virus biology.[24] Together with a long-term collaborator, Racaniello's lab has determined that neurotropism of Zika virus and enterovirus D 68 are not a recently acquired phenotypes. Results from their studies examining Zika virus infection of the neonatal mouse brain revealed that cortical developmental pathologies associated with virus infection may result from architecture defects of the developing brain. Data from their research understanding the mechanism of enterovirus D68 associated acute flaccid myelitis suggests multiple means by which paralysis may result from virus infection.[25][26]
In collaboration with members of the Center for Infection and Immunology at Columbia, Rosenfeld and Racaniello described a cross-reactive anti-enterovirus antibody response.[27] These results challenge the idea that enterovirus infections are modulated solely by a homotypic humoral immune response.
Science beyond the laboratory
Understanding that the World Wide Web is a primary scientific tool, Racaniello is one of the co-creators of BioCrowd,
Patents
Racaniello is listed as inventor on at least 12 patents.[43]
References
- ^ "Department of Microbiology and Immunology at Columbia University's College of Physicians and Surgeons".
- ISBN 978-1-55581-443-4.
- ^ "This Week in Virology". TWiV 662: Principals of Principles, Fifth Edition. 11 September 2020. Retrieved 16 September 2020.
- ^ "Richard R Ernst".
- ^ "Asv 2018".
- ^ "Journal of Virology". American Society for Microbiology. Retrieved 22 August 2014.
- ^ "PLOS Pathogens". PLOS. Retrieved 22 August 2014.
- ^ "Palese Laboratory". Icahn School of Medicine at Mount Sinai. Retrieved 22 August 2014.
- PMID 6272391.
- ^ "Vincent Racaniello, Ph.D." Columbia Faculty Profile: Vincent Racaniello. Department of Microbiology & Immunology, Columbia University. Retrieved 22 August 2014.
- PMID 3020560.
- S2CID 44296539.
- PMID 11333877.
- PMID 10770940.
- S2CID 11946113.
- PMID 15199409.
- PMID 2555543.
- PMID 19211759.
- PMID 17537857.
- PMID 15827151.
- PMID 12663784.
- PMID 19740998.
- PMID 14673080.
- ^ Racaniello, Vincent. "Research Interests of the Racaniello Lab". Columbia University. Retrieved 23 August 2014.
- PMID 29087938.
- PMID 31641090.
- PMID 5038922.
- ^ "BioCrowd". BioCrowd. Retrieved 22 August 2014.
- ^ Racaniello, Vincent. "Virology blog about viruses and viral disease". Vincent Racaniello. Retrieved 22 August 2014.
- ^ Racaniello, Vincent. "TWIV this week in virology". Vincent Racaniello. Retrieved 22 August 2014.
- ^ "This Week in Parasitism". Microbe World. American Society for Microbiology. Archived from the original on 16 August 2014. Retrieved 22 August 2014.
- ^ "Dr. Dickson Despommier". Columbia University. Retrieved 22 August 2014.
- ^ "This Week in Microbiology". Microbe World. American Society for Microbiology. Retrieved 22 August 2014.
- ^ "This Week in Evolution". Microbe World. American Society for Microbiology. Retrieved 22 August 2014.
- ^ "Nels Elde". University of Utah. Retrieved 22 August 2014.
- ^ "Immune". Microbe World. American Society for Microbiology. Retrieved 22 August 2014.
- ^ Racaniello, Vincent. "Influenza 101". Vincent Racaniello. Retrieved 22 August 2014.
- ^ Racaniello, Vincent. "Virology 101". Vincent Racaniello. Retrieved 22 August 2014.
- ^ Racaniello, Vincent. "Virology – Biology W3310/4310". V. Racaniello. Retrieved 22 August 2014.
- ^ Racaniello, Vincent. "Virology Live". YouTube.
- ^ Racaniello, Vincent. "Q&A with A&V Livestream". YouTube.
- ^ Racaniello, Vincent. "Office Hours with Earth's Virology Professor". YouTube.
- ^ Patents
- Racaniello, Vincent; Cathy Mendelsohn; Frank Costantini (1998-05-19), Molecular cloning of genomic and CDNA sequences encoding cellular receptors for poliovirus, retrieved 2014-08-24
- Racaniello, Vincent; Joanne M. Tatem; Carolyn L. Weeks-Levy (1996-06-11), Method for producing RNA viruses from cDNA, retrieved 2014-08-24
- Ticehurst, John R.; David Baltimore; Stephen M. Feinstone; Robert H. Purcell; Vincent R. Racaniello; Bahige M. Baroudy (1996-05-14), Methods of detecting hepatitis A virus, retrieved 2014-08-24
- Almond, Jeffrey W.; Michael a Skinner; Vincent Racaniello; Philip D. Minor (1994-02-15), Attenuated polioviruses, retrieved 2014-08-24
- Almond, Jeffrey William; Road London; Michael Anthony Skinner; Hills Road Biology; Vincent Racaniello; Surgeons of Columbia University 701; Philip David Minor; Blanche Lane South Mimms Control (1993-08-15), Attenuierte Viren., retrieved 2014-08-24
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- Racaniello, Vincent; Joanne Marie Tatem; Carolyn L. Weeks-Levy (1992-04-16), Foerfaranden Foer Framstaellning Av Rna-Virus Fraon Cdna., retrieved 2014-08-24
- Ticehurst, John; David Baltimore; Stephen Feinstone; Robert Purcell; Vincent Racaniello; Bahige Baroudy (1991-03-15), Herstellung Von Cdna Die Hepatitis a Virale Sequenzen Darstellen., retrieved 2014-08-24
- Baltimore, David; Vincent Racaniello; University of columbia (1990-10-15), Cdna Representierende Rna-Virensequenzen., retrieved 2014-08-24
- Racaniello, Vincent; Cathy Mendelsohn; Frank Costantini (1990-09-20), MOLECULAR CLONING OF GENOMIC AND cDNA SEQUENCES ENCODING CELLULAR RECEPTORS FOR POLIOVIRUS, retrieved 2014-08-24
- Jeffrey, William Almond; a Skinner Michael; Racaniello Vincent; David Minor Philip (1989-09-27), Attenuated Viruses, retrieved 2014-08-24
- Baltimore, David; Vincent R. Racaniello (1988-01-12), Production of complementary DNA representing RNA viral sequences by recombinant DNA methods and uses therefor, retrieved 2014-08-24
- Ticechurst, John; David Baltimore; Stephen Feinstone; Robert Purcell; Vincent Racaniello; Bahige Baroudy (1985-04-11), PRODUCTION OF cDNA REPRESENTING HEPATITIS A VIRAL SEQUENCES, retrieved 2014-08-24