ADAMTS
ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) is a family of multidomain extracellular
procollagens and von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan, making them key remodeling enzymes of the extracellular matrix. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration.[3][4] Homologous subfamily of ADAMTSL (ADAMTS-like) proteins, which lack enzymatic activity, has also been described.[5] Most cases of thrombotic thrombocytopenic purpura arise from autoantibody-mediated inhibition of ADAMTS13
.
Like
ADAMs, the name of the ADAMTS family refers to its disintegrin and metalloproteinase activity, and in the case of ADAMTS, the presence of a thrombospondin
motif.
ADAMTS family members
- antiangiogenic
- ADAMTS2
- ADAMTS3
- ADAMTS4
- ADAMTS5 (=ADAMTS11)
- ADAMTS6
- ADAMTS7
- ADAMTS8 (or METH-2), an antiangiogenic[7]
- ADAMTS9
- ADAMTS10
- ADAMTS12
- ADAMTS13
- ADAMTS14
- ADAMTS15
- ADAMTS16
- ADAMTS17
- ADAMTS18
- ADAMTS19
- ADAMTS20
See also
- A disintegrin and metalloproteinase(ADAM) family
- ADAMTSL family (ADAMTS-like proteins)