ADCY8
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| Location (UCSC) | n/a | Chr 15: 64.57 – 64.79 Mb | |||||||
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Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene.[4][5]
Function
cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase.[5]
References
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022376 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 7559521.
- ^ a b "Entrez Gene: ADCY8 adenylate cyclase 8 (brain)".
External links
- Human ADCY3 genome location and ADCY3 gene details page in the UCSC Genome Browser.
- Human ADCY8 genome location and ADCY8 gene details page in the UCSC Genome Browser.
Further reading
- Stengel D, Parma J, Gannagé MH, Roeckel N, Mattei MG, Barouki R, Hanoune J (1992). "Different chromosomal localization of two adenylyl cyclase genes expressed in human brain". Human Genetics. 90 (1–2): 126–30. S2CID 1740589.
- Parma J, Stengel D, Gannage MH, Poyard M, Barouki R, Hanoune J (Aug 1991). "Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain". Biochemical and Biophysical Research Communications. 179 (1): 455–62. PMID 1715695.
- Cali JJ, Zwaagstra JC, Mons N, Cooper DM, Krupinski J (Apr 1994). "Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain". The Journal of Biological Chemistry. 269 (16): 12190–5. PMID 8163524.
- Gu C, Cooper DM (Mar 1999). "Calmodulin-binding sites on adenylyl cyclase type VIII". The Journal of Biological Chemistry. 274 (12): 8012–21. PMID 10075700.
- Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP (Mar 1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1". Pflügers Archiv. 437 (4): 538–46. S2CID 7620262.
- Speth C, Joebstl B, Barcova M, Dierich MP (Apr 2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones". AIDS. 14 (6): 629–36. S2CID 22105709.
- Patke CL, Shearer WT (May 2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". The Journal of Allergy and Clinical Immunology. 105 (5): 975–82. PMID 10808179.
- Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. PMID 11076863.
- Patrizio M, Colucci M, Levi G (Apr 2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures". Journal of Neurochemistry. 77 (2): 399–407. S2CID 24053412.
- Parkinson NA, Bolsover SR (Jul 2001). "A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones". Brain Research. Molecular Brain Research. 91 (1–2): 43–9. PMID 11457491.
- Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP (Apr 2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons". Journal of Virology. 76 (7): 3179–88. PMID 11884542.
- Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms". Journal of Receptor and Signal Transduction Research. 22 (1–4): 79–110. S2CID 36697419.
- Georget M, Mateo P, Vandecasteele G, Lipskaia L, Defer N, Hanoune J, Hoerter J, Lugnier C, Fischmeister R (Aug 2003). "Cyclic AMP compartmentation due to increased cAMP-phosphodiesterase activity in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8)" (PDF). FASEB Journal. 17 (11): 1380–91. S2CID 17921962.
- Crossthwaite AJ, Ciruela A, Rayner TF, Cooper DM (Feb 2006). "A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A". Molecular Pharmacology. 69 (2): 608–17. S2CID 10661331.
- Simpson RE, Ciruela A, Cooper DM (Jun 2006). "The role of calmodulin recruitment in Ca2+ stimulation of adenylyl cyclase type 8". The Journal of Biological Chemistry. 281 (25): 17379–89. PMID 16613843.
- Nlend MC, Schmid A, Sutto Z, Ransford GA, Conner GE, Fregien N, Salathe M (Jul 2007). "Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia". FEBS Letters. 581 (17): 3241–6. PMID 17586501.
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