Atrial natriuretic peptide receptor
An atrial natriuretic peptide receptor is a
receptor for atrial natriuretic peptide.[1]
Mechanism
NPRA and NPRB are linked to guanylyl cyclases, while NPRC is G-protein-linked and is a "clearance receptor" that acts to internalise and destroy the ligand.
ANP activation of the ANP
total peripheral resistance, which will in turn decrease venous return to the heart. The decrease in venous return to the heart will reduce the preload
and will result in the heart's having to do less work.
There is also a
nitroglycerine is given to a person having a heart attack. The nitroglycerine will be metabolized to nitric oxide, which will stimulate soluble guanylyl cyclase. This will result in a decrease in total peripheral resistance and a decrease in preload on the heart. As a result, work done by the heart will decrease and will allow the heart to contract less strongly. Weaker contractions will lead to more blood flow in the coronary arteries
, which will help the ischemic cardiac myocytes.
Types
There are three distinct atrial natriuretic factor receptors identified so far in mammals: natriuretic peptide receptors 1, 2, and 3.
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References
- PMID 11558675.
External links
- Atrial+Natriuretic+Factor+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)