Acitretin

Source: Wikipedia, the free encyclopedia.

Acitretin
Clinical data
Trade namesSoriatane, Neotigason
AHFS/Drugs.comMonograph
MedlinePlusa601010
Pregnancy
category
  • AU: X (High risk)
By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability60%
Protein binding>99.9%
MetabolismLiver
Elimination half-life49 hours
ExcretionFaeces & urine
Identifiers
  • (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
JSmol)
  • O=C(O)\C=C(\C=C\C=C(\C=C\c1c(cc(OC)c(c1C)C)C)C)C
  • InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+ checkY
  • Key:IHUNBGSDBOWDMA-AQFIFDHZSA-N checkY
  (verify)

Acitretin, sold under the brand name Neotigason among others, is a second-generation retinoid. It is taken orally, and is typically used for psoriasis.[5]

Acitretin is an oral retinoid used in the treatment of severe resistant psoriasis. Because of the potential for problems and severe side effects it is generally used in only very severe cases of psoriasis that have been unresponsive to other treatments. It binds to nuclear receptors that regulates gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia, leading to the slowing of cell reproduction. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after two to four weeks or longer.

Patients who have received the medication are advised against giving blood for at least three years due to the risk of birth defects.[6]

Adverse effects

Acitretin is highly

cystic acne or hair loss.[7][8][9]

Pharmacokinetics

It is a metabolite of

elimination half-life (t1/2 = 120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days. However, because acitretin can be reverse metabolised into etretinate which has an extremely long half-life, women must avoid becoming pregnant for at least three years[10]
after discontinuing acitretin. Therefore, acitretin is generally not recommended for women of child-bearing age with a risk of becoming pregnant.

Society and culture

Brand names

It is sold under the brand names Soriatane[4] and Neotigason.[2]

References

  1. FDA
    . Retrieved 22 October 2023.
  2. ^ a b NEOTIGASON acitretin 10mg capsule blister pack (52455) Australian Department of Health and Aged Care
  3. ^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 15 August 2023.
  4. ^ a b "Soriatane (acitretin) Capsules". dailymed.nlm.nih.gov. Retrieved 30 December 2023.
  5. PMID 30137855
    .
  6. ^ AABB Technical Manual, American Association of Blood Banks
  7. ^ "Soriatane". WebMD. Retrieved 15 August 2015.
  8. ^ "Soriatane Side Effects". Drugs.com. Retrieved 15 August 2015.
  9. ^ "Soriatane (Acitretin) Drug Information: Description, User Reviews, Drug Side Effects, Interactions - Prescribing Information at RxList". RxList. Archived from the original on 2 December 2013. Retrieved 15 August 2015.
  10. ^ "Important Safety Information for SORIATANE". soriatane.com. Retrieved 31 October 2015.
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