Cholecystokinin receptor

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Chr. 11 p15.4
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Cholecystokinin receptors or CCK receptors are a group of

G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin.[1] There are two different subtypes CCKA and CCKB which are ~50% homologous:[2] Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide
.

Protein Gene Tissue distribution Preferred ligand Function Mechanism
CCKA (CCK1) CCKAR primarily gastrointestinal tract, lesser amounts in the CNS sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility Gq[3][4]
CCKB (CCK2) CCKBR primarily CNS, lesser amounts in the gastrointestinal tract gastrin ≈ CCK (receptor does not discriminate between sulfated and nonsulfated peptides) regulation of nociception, anxiety, memory and hunger Gq/G11[4]

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