Thyrotropin-releasing hormone receptor
| TRHR | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 8: 109.09 – 109.12 Mb | Chr 15: 44.06 – 44.1 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Thyrotropin-releasing hormone receptor (TRHR) is a
The TRHR is found on the cell membrane of
diacylglycerol (DAG). This leads to an increase in cytoplasmic calcium ion concentrations which stimulates the exocytosis of thyroid-stimulating hormone
(TSH) into the blood.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000174417 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038760 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 44982871.
- )
Further reading
- Yamada M, Iwasaki T, Satoh T, Monden T, Konaka S, Murakami M, Iriuchijima T, Mori M (August 1995). "Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly". Neuroscience Letters. 196 (1–2): 109–12. S2CID 45874879.
- Hinuma S, Hosoya M, Ogi K, Tanaka H, Nagai Y, Onda H (October 1994). "Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1219 (2): 251–9. PMID 7918619.
- Morrison N, Duthie SM, Boyd E, Eidne KA, Connor JM (June 1994). "Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization". Human Genetics. 93 (6): 716–8. S2CID 804377.
- Yamada M, Monden T, Konaka S, Mori M (November 1993). "Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8". Somatic Cell and Molecular Genetics. 19 (6): 577–80. S2CID 44982871.
- Duthie SM, Taylor PL, Anderson L, Cook J, Eidne KA (September 1993). "Cloning and functional characterisation of the human TRH receptor". Molecular and Cellular Endocrinology. 95 (1–2): R11-5. S2CID 21150474.
- Matre V, Karlsen HE, Wright MS, Lundell I, Fjeldheim AK, Gabrielsen OS, Larhammar D, Gautvik KM (August 1993). "Molecular cloning of a functional human thyrotropin-releasing hormone receptor". Biochemical and Biophysical Research Communications. 195 (1): 179–85. PMID 8395824.
- Yamada M, Monden T, Satoh T, Satoh N, Murakami M, Iriuchijima T, Kakegawa T, Mori M (September 1993). "Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene". Biochemical and Biophysical Research Communications. 195 (2): 737–45. PMID 8396925.
- Iwasaki T, Yamada M, Satoh T, Konaka S, Ren Y, Hashimoto K, Kohga H, Kato Y, Mori M (September 1996). "Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene". The Journal of Biological Chemistry. 271 (36): 22183–8. PMID 8703031.
- Cook JV, McGregor A, Lee T, Milligan G, Eidne KA (July 1996). "A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor". Endocrinology. 137 (7): 2851–8. PMID 8770906.
- Collu R, Tang J, Castagné J, Lagacé G, Masson N, Huot C, Deal C, Delvin E, Faccenda E, Eidne KA, Van Vliet G (May 1997). "A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene". The Journal of Clinical Endocrinology and Metabolism. 82 (5): 1561–5. S2CID 18861350.
- Petrou C, Tashjian AH (September 1998). "The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles". Cellular Signalling. 10 (8): 553–9. PMID 9794253.
- Matre V, Høvring PI, Orstavik S, Frengen E, Rian E, Velickovic Z, Murray-McIntosh RP, Gautvik KM (January 1999). "Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor". Journal of Neurochemistry. 72 (1): 40–50. S2CID 6665620.
- Kroeger KM, Hanyaloglu AC, Seeber RM, Miles LE, Eidne KA (April 2001). "Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer". The Journal of Biological Chemistry. 276 (16): 12736–43. PMID 11278883.
- Zhu CC, Cook LB, Hinkle PM (August 2002). "Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation". The Journal of Biological Chemistry. 277 (31): 28228–37. PMID 12023974.
- Hanyaloglu AC, Seeber RM, Kohout TA, Lefkowitz RJ, Eidne KA (December 2002). "Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2". The Journal of Biological Chemistry. 277 (52): 50422–30. PMID 12393857.
- Cook LB, Zhu CC, Hinkle PM (September 2003). "Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation". Molecular Endocrinology. 17 (9): 1777–91. PMID 12805411.
- Igarashi-Migitaka J, Yamada S, Hara M, Sano T, Ozawa Y, Ohtani-Kaneko R, Hirata K (August 2003). "Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas". Endocrine Journal. 50 (4): 459–67. PMID 14599121.
- Cook LB, Hinkle PM (July 2004). "Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein". Endocrinology. 145 (7): 3095–100. PMID 15117874.
External links
- "Thyrotropin-Releasing Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2012-09-08. Retrieved 2007-10-25.
- Receptors,+Thyrotropin-Releasing+Hormone at the U.S. National Library of Medicine Medical Subject Headings (MeSH)