Neuropeptide FF receptor

Chr. 10 q21-q22
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Chr. 4 q21
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The neuropeptide FF receptors

The Neuropeptide FF receptor family is a member of the G protein-coupled receptor superfamily containing two subtypes, NPFF1 and NPFF2, which exhibit a high affinity for Neuropeptide FF (NPFF) peptides. NPFF1 is broadly distributed in the central nervous system with the highest levels found in the limbic system and the hypothalamus. NPFF2 is present in high density, particularly in mammals in the superficial layers of the spinal cord where it is involved in nociception and modulation of opioid functions. These receptors participate to the modulation of opioid receptor function in the brain and spinal cord, and can either reduce or increase opioid receptor function depending which tissue they are released in, reflecting a complex role for neuropeptide FF in pain responses. ^{[3][4][5][6][7]}

NPFF receptors are coupled to G proteins and regulate adenylyl cyclase in recombinant cell lines (CHO, HEK 293, SH-SY5Y). NPFF receptors are also coupled to voltage-gated N-type Ca2+ channels.

Ligands

Agonists

• Neuropeptide AF
• Neuropeptide FF
• Neuropeptide SF (RFRP-1)
• Neuropeptide VF (RFRP-3)

Antagonists

• BIBP-3226 (mixed NPFF₁ / NPY₁ antagonist)^[8][9]
• RF-9^[10][11]

References

External links

• "Neuropeptide FF Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-11-03.
• neuropeptide+FF+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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