Type I cytokine receptor
| Type I cytokine receptor, cytokine-binding domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | TypeI_recpt_CBD | ||||||||
SCOP2 | 1n26 / SCOPe / SUPFAM | ||||||||
| Membranome | 2 | ||||||||
| |||||||||
Type I WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.
The common cytokine-binding domain is related to the Fibronectin type III domain.
Signal transduction chains
The signal transducing chains are often shared between different receptors within this receptor family.[1]
- The IL-2 receptor common gamma chain (also known as CD132) is shared between:
- IL-2 receptor
- IL-4 receptor
- IL-7 receptor
- IL-9 receptor
- IL-13 receptor
- IL-15 receptor[2]
- IL-21 receptor[3]
- The common beta chain (CD131or CDw131) is shared between the following type I cytokine receptors:
- GM-CSF receptor
- IL-3 receptor
- IL-5 receptor.[4]
- The gp130 receptor (Glycoprotein 130) (also known as gp130, IL6ST, IL6-beta or CD130) is shared between:
- IL-6 receptor
- IL-11 receptor
- IL-12 receptor
- IL-27 receptor
- Leukemia inhibitory factor receptor
- Oncostatin M receptor
Examples
Type I cytokine receptors include
colony stimulating factor
receptors and other cytokine receptors
Interleukin receptors
- Interleukin-1 receptor
- Interleukin-2 receptor
- Interleukin-3 receptor
- Interleukin-4 receptor
- Interleukin-5 receptor
- Interleukin-6 receptor
- Interleukin-7 receptor
- Interleukin-9 receptor
- Interleukin-11 receptor
- Interleukin-12 receptor
- Interleukin-13 receptor
- Interleukin-15 receptor
- Interleukin-18 receptor
- Interleukin-21 receptor
- Interleukin-23 receptor
- Interleukin-27 receptor
Colony stimulating factor receptors
- Erythropoietin receptor
- GM-CSF receptor
- G-CSF receptor
- Thrombopoietin receptor
Hormone receptor/neuropeptide receptor
Other
References
- ISBN 0-7216-0008-5.
- PMID 7530740.
- PMID 11418623.
- PMID 9422786.
- PMID 18821585.
External links
- Cytokine+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)