Bombesin
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Other names
Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
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Identifiers | |
3D model (
JSmol ) |
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ChEMBL | |
ChemSpider | |
IUPHAR/BPS |
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PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C71H110N24O18S | |
Molar mass | 1619.85 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Bombesin is a 14-
G-protein-coupled receptors known as BBR1, -2, and -3.[4] It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative feedback signals that stop eating behaviour.[5]
Bombesin is also a
tumor marker for small cell carcinoma of lung, gastric cancer, pancreatic cancer, and neuroblastoma.[6]
Receptors
The
anuran BB4 receptor homologue is termed frog BB4 (fBB4).[3] Iwabuchi et al. 2003 discovered a chicken (Gallus domesticus) receptor which is homologous to both the mammalian BB3 and fBB4 and so they named it chBRS-3.5.[3]
Effects
Erspamer 1988 finds bombesin has a similar effect on the chicken to ranatensin, unreliably increasing or decreasing blood pressure.[7]