Physalaemin

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Physalaemin
Names
Other names
H-Pyr-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2
Identifiers
3D model (
JSmol
)
ChEMBL
IUPHAR/BPS
MeSH Physalaemin
UNII
  • C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)[C@@H]4CCC(=O)N4
Properties
C58H84N14O16S
Molar mass 1265.45 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Physalaemin is a tachykinin peptide obtained from the Physalaemus frog, closely related to substance P. Its structure was first elucidated in 1964.[1][2]

Like all tachykinins, physalaemin is a

hypotensive effects.[3]

Structure

Physalaemin (PHY) is known to take on both a linear and helical three dimensional structure. Grace et al. (2010) have shown that in aqueous environments,  PHY preferentially takes on the linear conformation whereas in an environment that simulates a cellular membrane, PHY takes on a helical confirmation from the Pro4 residue to the C-Terminus. This helical conformation is essential to allow the binding of PHY to neurokinin-1 (NK1) receptors. Consensus sequences between Substance P (a mammalian tachykinin and agonist of NK1) and PHY have been used to confirm that the helical confirmation is necessary for PHY to bind to NK1.[4]

Use In Research

Not only is PHY closely related to Substance P (SP), but it also has a higher affinity for the mammalian neurokinin receptors that Substance P can bind to. Researchers can make use of this behavior of PHY to study the behavior of smooth muscle -  a tissue where NK1 can be found. Shiina et al. (2010) used PHY to show that tachykinins as a whole can cause the longitudinal contraction of smooth muscle tissue in esophageal tissue.[5]

Singh et Maji made use of PHY's similarity to SP along with its sequence similarity to Amyloid B-peptide 25-35 [AB(25-35)]. Despite its sequence similarity to SP, Singh et Maji showed that PHY had distinct amyloid forming capabilities . Under artificially elevated concentrations of tetrafluoroethylene (TFE) and a short incubation time, PHY was able to form amyloid fibrils. These fibrils originating from tackynins like PHY were also shown to reduce the neurotoxicity of other Amyloid fibers associated with amyloid induced diseases such as  Alzheimer's disease.[6]

References

  1. S2CID 25448266
    .
  2. PMID 14240587
    .
  3. S2CID 85570180
    .
  4. PMID 20632396
    .
  5. PMID 19958761
    .
  6. S2CID 17460410
    .


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