Butamirate

Butamirate

Clinical data
Trade names	Acodeen, Codesin, Pertix, Sinecod, Sinecoden, Sinecodix
AHFS/Drugs.com	International Drug Names
ATC code	R05DB13 (WHO)
Pharmacokinetic data
Protein binding	98%
Elimination half-life	6 hours
Excretion	90% renal
Identifiers
IUPAC name 2-(2-diethylaminoethoxy)ethyl 2-phenylbutanoate
JSmol)	Interactive image
SMILES O=C(OCCOCCN(CC)CC)C(c1ccccc1)CC
InChI InChI=1S/C18H29NO3/c1-4-17(16-10-8-7-9-11-16)18(20)22-15-14-21-13-12-19(5-2)6-3/h7-11,17H,4-6,12-15H2,1-3H3 Y Key:DDVUMDPCZWBYRA-UHFFFAOYSA-N Y
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Butamirate (or brospamin, trade names Acodeen, Codesin, Pertix, Sinecod, Sinecoden, Sinecodix) is a

A study found it to bind to the cough center in the medulla oblongata, more specifically the dextromethorphan-binding site in guinea pig brain with high affinity.^[3]

As a 2-(2-diethylaminoethoxy)ethyl ester, it is chemically related to oxeladin and pentoxyverine, which are in the same class. (Oxeladin has an additional ethyl group in its carboxylic acid, pentoxyverine has both ethyl groups of oxeladin replaced by one cyclopentyl in the same place.)

• 
  Oxeladin
• 
  Pentoxyverine

See also

• Cough syrup
• Noscapine
• Codeine; Pholcodine
• Dextromethorphan; Dimemorfan
• Racemorphan; Dextrorphan; Levorphanol
• Pentoxyverine
• Tipepidine
• Cloperastine; Levocloperastine

References