CENPF
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| Location (UCSC) | Chr 1: 214.6 – 214.66 Mb | Chr 1: 189.37 – 189.42 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Centromere protein F is a
Function
CENPF is part of the
intercellular bridge. It is thought to be subsequently degraded. Mutations in CENPF lead to impaired cell division during early development. Mitosis has been found to take longer when the gene is mutated.[8][9]
Microtubules are protein structures that are part of the
cell signalling to trigger migration, division or differentiation. Mutations in CENPF disrupt this ability to form cilia; cilia have been found to be fewer in number and shorter when the gene is mutated.[8][10]
CENPF is thought to form either a
heterodimer
.
Clinical significance
Mutations in both copies of CENPF cause
Autoantibodies against CENPF have been found in patients with cancer or graft-versus-host disease.[7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000117724 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026605 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 7904902.
- PMID 7851898.
- ^ a b "Entrez Gene: CENPF centromere protein F, 350/400ka (mitosin)".
- ^ PMID 25564561.
- ^ S2CID 1495539.
- ^ "OMIM Entry - # 243605 - STROMME SYNDROME; STROMS". www.omim.org. Retrieved 2018-09-27.
- S2CID 1495539.
External links
- Human CENPF genome location and CENPF gene details page in the UCSC Genome Browser.
Further reading
- Ma L, Zhao X, Zhu X (2006). "Mitosin/CENP-F in mitosis, transcriptional control, and differentiation". J. Biomed. Sci. 13 (2): 205–13. PMID 16456711.
- Liao H, Winkfein RJ, Mack G, et al. (1995). "CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis". J. Cell Biol. 130 (3): 507–18. PMID 7542657.
- Li Q, Ke Y, Kapp JA, et al. (1995). "A novel cell-cycle-dependent 350-kDa nuclear protein: C-terminal domain sufficient for nuclear localization". Biochem. Biophys. Res. Commun. 212 (1): 220–8. PMID 7612011.
- Zhu X, Chang KH, He D, et al. (1995). "The C terminus of mitosin is essential for its nuclear localization, centromere/kinetochore targeting, and dimerization". J. Biol. Chem. 270 (33): 19545–50. PMID 7642639.
- Zhu X, Mancini MA, Chang KH, et al. (1995). "Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression". Mol. Cell. Biol. 15 (9): 5017–29. PMID 7651420.
- Li S, Ku CY, Farmer AA, et al. (1998). "Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs". J. Biol. Chem. 273 (11): 6183–9. PMID 9497340.
- Chan GK, Schaar BT, Yen TJ (1998). "Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1". J. Cell Biol. 143 (1): 49–63. PMID 9763420.
- Zhu X (1999). "Structural requirements and dynamics of mitosin-kinetochore interaction in M phase". Mol. Cell. Biol. 19 (2): 1016–24. PMID 9891037.
- Erlanson M, Casiano CA, Tan EM, et al. (1999). "Immunohistochemical analysis of the proliferation associated nuclear antigen CENP-F in non-Hodgkin's lymphoma". Mod. Pathol. 12 (1): 69–74. PMID 9950165.
- Goodwin RL, Pabón-Peña LM, Foster GC, Bader D (1999). "The cloning and analysis of LEK1 identifies variations in the LEK/centromere protein F/mitosin gene family". J. Biol. Chem. 274 (26): 18597–604. PMID 10373470.
- Ashar HR, James L, Gray K, et al. (2000). "Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules". J. Biol. Chem. 275 (39): 30451–7. PMID 10852915.
- Kobayashi M, Hanai R (2001). "M phase-specific association of human topoisomerase IIIbeta with chromosomes". Biochem. Biophys. Res. Commun. 287 (1): 282–7. PMID 11549288.
- Hussein D, Taylor SS (2003). "Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis". J. Cell Sci. 115 (Pt 17): 3403–14. PMID 12154071.
- Holstein SA, Hohl RJ (2003). "Synergistic interaction of lovastatin and paclitaxel in human cancer cells". Mol. Cancer Ther. 1 (2): 141–9. PMID 12467231.
- Konstantinidou AE, Korkolopoulou P, Kavantzas N, et al. (2003). "Mitosin, a novel marker of cell proliferation and early recurrence in intracranial meningiomas". Histol. Histopathol. 18 (1): 67–74. PMID 12507285.
- Yang ZY, Guo J, Li N, et al. (2004). "Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport". Cell Res. 13 (4): 275–83. PMID 12974617.
- Laoukili J, Kooistra MR, Brás A, et al. (2005). "FoxM1 is required for execution of the mitotic programme and chromosome stability". Nat. Cell Biol. 7 (2): 126–36. S2CID 11732068.
- Zhou X, Wang R, Fan L, et al. (2005). "Mitosin/CENP-F as a negative regulator of activating transcription factor-4". J. Biol. Chem. 280 (14): 13973–7. PMID 15677469.