CENPH
| CENPH | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 5: 69.19 – 69.21 Mb | Chr 13: 100.76 – 100.78 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
| CENP-H | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | CENP-H | ||||||||
| Pfam | PF05837 | ||||||||
| InterPro | IPR008426 | ||||||||
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Centromere protein H is a protein that in humans is encoded by the CENPH gene.[5][6][7] It is involved in the assembly of kinetochore proteins, mitotic progression and chromosome segregation.[8][9]
Function
CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.[11] CENP-H contains a coiled-coil structure and a nuclear localisation signal.[11]
Studies show that CENP-H may be associated with certain
CENP-H shows
sequence similarity to the Schizosaccharomyces pombe kinetochore protein Fta3 which is a subunit of the Sim4 complex. This complex is required for loading the DASH complex onto the kinetochore via interaction with dad1. Fta2, Fta3 and Fta4 associate with the central core and inner repeat region of the centromere.[14]
Interactions
CENPH has also been shown to interact with KIAA0090.[15] The significance of this interaction is unclear.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000153044 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045273 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 11092768.
- S2CID 39408000.
- ^ "Entrez Gene: CENPH centromere protein H".
- PMID 18007590.
- PMID 16875666.
- PMID 11500386.
- ^ PMID 10488063.
- PMID 18700042.
- S2CID 474452.
- PMID 16079914.
- PMID 16845013. Archived from the originalon 2010-04-09.
External links
- Human CENPH genome location and CENPH gene details page in the UCSC Genome Browser.
- Human PMF1 genome location and PMF1 gene details page in the UCSC Genome Browser.
Further reading
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–16903. PMID 12477932.
- Saffery R, Sumer H, Hassan S, Wong LH, Craig JM, Todokoro K, et al. (August 2003). "Transcription within a functional human centromere". Molecular Cell. 12 (2): 509–516. PMID 14536089.
- Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (February 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–120. S2CID 21813024.
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (October 2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–2127. PMID 15489334.
- Mikami Y, Hori T, Kimura H, Fukagawa T (March 2005). "The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosis". Molecular and Cellular Biology. 25 (5): 1958–1970. PMID 15713649.
- Tomonaga T, Matsushita K, Ishibashi M, Nezu M, Shimada H, Ochiai T, et al. (June 2005). "Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy". Cancer Research. 65 (11): 4683–4689. PMID 15930286.
- Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–469. S2CID 205286556.
- Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, et al. (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–457. S2CID 26974412.
- Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, et al. (June 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673–684. S2CID 45931410.
- Orthaus S, Ohndorf S, Diekmann S (September 2006). "RNAi knockdown of human kinetochore protein CENP-H". Biochemical and Biophysical Research Communications. 348 (1): 36–46. PMID 16875666.
- Liao WT, Song LB, Zhang HZ, Zhang X, Zhang L, Liu WL, et al. (January 2007). "Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival". Clinical Cancer Research. 13 (2 Pt 1): 508–514. S2CID 474452.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. PMID 17353931.
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