Cat coat genetics

Cat coat genetics determine the coloration, pattern, length, and texture of feline fur. The variations among cat coats are physical properties and should not be confused with cat breeds. A cat may display the coat of a certain breed without actually being that breed. For example, a Neva Masquerade (Siberian colorpoint) could wear point coloration, the stereotypical coat of a Siamese.

Solid colors

Eumelanin and phaeomelanin

Eumelanin

The browning gene B/b/b^l codes for TYRP1 (Q4VNX8), an enzyme involved in the metabolic pathway for eumelanin pigment production. Its dominant form, B, will produce black eumelanin. It has two recessive variants, b (chocolate) and b^l (cinnamon), with b^l being recessive to both B and b.^[1] Chocolate is a rich dark brown color, and is referred to as chestnut in some breeds. Cinnamon is a light, reddish brown, but is sometimes not reddish at all.

Basic colors

A male red tabby showing the X^OY-genotype

A female black tortoiseshell cat showing the X^OX^o-genotype

Sex-linked red

Diluted colors

A cream (diluted red) tabby cat

A blue (diluted black) tortoiseshell cat

The

The pelt color commonly referred to as "orange" is scientifically known as red. Other common names include yellow, ginger, and marmalade. Red show cats have a deep orange color, but it can also present as a yellow or light ginger color. Unidentified "rufousing polygenes" are theorized to be the reason for this variance. Orange is epistatic to nonagouti, so all red cats are tabbies. "Solid" red show cats are usually low contrast ticked tabbies.^[5]

The precise identity of the gene at the Orange locus is unknown. It has been narrowed down to a 3.5 Mb stretch on the X chromosome in 2009.^[5]

Dilution

The Dense pigment gene, D/d, codes for melanophilin (MLPH; A0SJ36), a protein involved in the transportation and deposition of pigment into a growing hair.^[5] When a cat has two of the recessive d alleles (Maltese dilution), black fur becomes "blue" (appearing gray), chocolate fur becomes "lilac" (appearing light, almost grayish brown-lavender), cinnamon fur becomes "fawn", and red fur becomes "cream".^[6] Similar to red cats, all cream cats are tabbies. The d allele is a single-base deletion that truncates the protein. If the cat has d/d genes, the coat is diluted. If the genes are D/D or D/d, the coat will be unaffected.^[5]

Other genes

• Barrington Brown is a recessive browning gene that dilutes black to mahogany, brown to light brown and chocolate to pale coffee. It is different from the browning gene and has only been observed in laboratory cats.^[7]
• The Dilution modifier gene, Dm, "caramelizes" the dilute colors as a dominant trait. The existence of this phenomenon as a discrete gene is a controversial subject among feline enthusiasts.^{[citation needed]}
• Amber, a mutation at the extension locus E/e (the melanocortin 1 receptor, MC1R) changes black pigment to amber or light amber, similar in appearance to red and cream. Kittens are born dark but lighten up as they age. Paws and nose still exhibit the original undiluted color, this in contrast to other diluted colors, where paws and nose have the diluted color. This phenomenon was first identified in Norwegian Forest cats.^[8]
• Another recessive mutation at extension was discovered which causes the russet color in Burmese cats. It is symbolized as e^r. Like amber cats, russet cats lighten as they age.^[9]
• A modifying factor has also been hypothesized in shaded silver and chinchilla Persians whose fur turns pale golden in adulthood, due to low levels of phaeomelanin production. These cats resemble shaded or tipped goldens, but are genetically shaded or tipped silvers. This is probably related to the phenomenon known as "tarnishing" in silvers.

Tabbies

Tabby cats have a range of variegated and blotched coats, consisting of a dark pattern on a lighter background. This variety is derived from the interplay of multiple genes and resulting phenotypes. Most tabbies feature thin dark markings on the face, including the 'M' on the forehead and an eyeliner effect, pigmented lips and paws, and a pink nose outlined in darker pigment.^{[citation needed]} However, the following different coat patterns are all possible:^{[citation needed]}

• Mackerel: thin, dark stripes (sometimes called "tiger stripes")
• Blotched: thicker bands or whorls of dark pigment
• Spotted: broken bands that look more like individual spots
• Ticked: No distinct stripes, spots, or blotches

• 
  Mackerel
• 
  Blotched / classic
• 
  Spotted
• 
  Ticked

Agouti

The agouti factor determines the "background" of the tabby coat, which consists of hairs that are banded with dark eumelanin and lighter phaeomelanin along the length of the hair shaft. The

The wild-type (in African wildcats) is the mackerel tabby (stripes look like thin fishbones and may break up into bars or spots). The most common variant is the classic tabby pattern (broad bands, whorls, and spirals of dark color on pale background usually with bulls-eye or oyster pattern on flank).^[12] Spotted tabbies have their stripes broken up into spots, which may be arranged vertically or horizontally. A 2010 study suggests that spotted coats are caused by the modification of mackerel stripes, and may cause varying phenotypes such as "broken mackerel" tabbies via multiple loci. If the genes are Sp/Sp or Sp/sp the tabby coat will be spotted or broken. If it is an sp/sp gene, the tabby pattern will remain either mackerel or blotched. This gene has no effect on cats with a ticked coat.^[11]

Ticked tabby

The Ticked (Ti) locus on chromosome B1 controls the generation of "ticked coats", agouti coats with virtually no stripes or bars. Ticked tabbies are rare in the random-bred population, but fixed in certain breeds such as the Abyssinian and Singapura.^[13] Ti^A is the dominant allele that produces ticked coats; Ti⁺ is the recessive one. The causative gene for ticked tabby markings is Dickkopf-related protein 4 (DKK4).^[14] Both a cysteine to tyrosine substitution at residue 63 (C63Y) and an alanine to valine substitution at residue 18 (A18V) result in decreased DKK4, which is associated with . Both variants are present in the Abyssinian breed, and the A18V variant is found in the Burmese breed.^[13] Stripes often remain to some extent on the face, tail, legs, and sometimes the chest ("bleeding through"). Traditionally, this has been thought to happen in heterozygotes (Ti^ATi⁺) but be nearly or completely nonexistent in homozygotes (Ti^ATi^A). The ticked tabby allele is epistatic to and therefore completely (or mostly) masks all the other tabby alleles, "hiding" the patterns they would otherwise express.^[11]

It was once thought that Ti^A was an allele of the Tabby gene, called T^a, dominant to all other alleles at the locus.^[15]

Other genes

• Other genes (pattern modifier genes) are theorized to be responsible for creating various type of spotting patterns, many of which are variations on a basic mackerel or classic pattern. There are also hypothetical factors which affect the timing and frequency of the agouti shift, affecting agouti band width and the number and quality of alternating bands of eumelanin and phaeomelanin on individual hairs.
• There is a gene not yet identified, but believed to be related to the agouti gene in the
  hybridization of the domestic cat to the jungle cat
  (Felis chaus).
• The rosette tabby pattern is a pattern similar to that of a
  Safari.^{[16][unreliable source}
  ]
• The inhibited pigment gene, I/i. The dominant allele (I) produces tipped hairs that are fully colored only at the tip and have a white base. This allele appears to interact with other genes to produce various degrees of tipping, ranging from deeply tipped silver tabby to lightly tipped shaded silver and chinchilla silver. The inhibitor gene interacts with the non-agouti genotype (I-aa) to produce the color known as smoke. The homozygous recessive genotype when combined with the agouti gene (iiA-), produces tabby coloration, which can vary along a spectrum ranging from a deeply patterned brown tabby, to a lighter "golden tabby", to the very lightly colored shaded or chinchilla golden colors. Red and cream cats with the inhibitor gene (I-O-) are commonly called "cameo".

Tortoiseshells and calicos

Tortoiseshells have patches of orange fur (pheomelanin based) and black or brown (eumelanin based) fur, caused by X-inactivation. Because this requires two X chromosomes, the vast majority of tortoiseshells are female, with approximately 1 in 3,000 being male.^[17] Male tortoiseshells can occur as a result of chromosomal abnormalities such as Klinefelter syndrome, by mosaicism, or by a phenomenon known as chimerism, where two early stage embryos are merged into a single kitten.

Tortoiseshells with a relatively small amount of white spotting are known as "tortoiseshell and white", while those with a larger amount are known in the United States as calicos. Calicos are also known as tricolor cats, mi-ke (meaning "triple fur") in Japanese, and lapjeskat (meaning "patches cat") in Dutch. The factor that distinguishes tortoiseshell from calico is the pattern of eumelanin and pheomelanin, which is partly dependent on the amount of white, due to an effect of the white spotting gene on the general distribution of melanin. A cat which has both an orange and non-orange gene, Oo, and little to no white spotting, will present with a mottled blend of black/red and blue/cream, reminiscent of tortoiseshell material, and is called a tortoiseshell cat. An Oo cat with a large amount of white will have bigger, clearly defined patches of black/red and blue/cream, and is called a calico in the US.

With intermediate amounts of white, a cat may exhibit a calico pattern, a tortie pattern, or something in between, depending on other epigenetic factors. Blue tortoiseshell, or diluted calico, cats have a lighter coloration (blue/cream) and are sometimes called calimanco or clouded tiger.^[18]

A true tricolor must consist of three colors: white, a red-based color like ginger or cream, and black-based color like black or blue. Tricolor should not be mistaken for the natural gradations in a tabby pattern. The shades which are present in the pale bands of a tabby are not considered to constitute a separate color.^[19]

Variations

• The basic tortoiseshell pattern has several different colors depending on the color of the eumelanin (the B locus), and dilution (the D locus).
• Tortoiseshell tabbies, also known as torbies, display tabby patterning on both red- and black-based colors. Calico tabbies are also called calibys or tabicos.^[20]

Tortoiseshell cats with small white patches are called tortillo cats, a portmanteau of Calico and Tortoiseshell.^[21]

White spotting and epistatic white

White spotting locus

Dominant white; solid white Norwegian Forest cat

White spotting; blue (gray) and white bicolor cat

The KIT gene determines whether or not there will be any white in the coat, except when a solid white coat is caused by albinism. White spotting and epistatic white (also known as dominant white) were long thought to be two separate genes (called S and W respectively),^[22] but in fact they are both on the KIT gene. The two have been combined into a single white spotting locus (W). White spotting can take many forms, from a small spot of white to the mostly-white pattern of the Turkish Van, while epistatic white produces a fully white cat (solid or self white). The KIT gene W locus has the following alleles:^[22][23][24]

• W^D (or W)=dominant white (solid/self white), autosomal dominant allele. It causes complete white coloration by disrupting replication and migration of melanocytes into the skin. The carriers of this allele are white regardless of any other color-associated gene. It is linked to blue eyes and congenital sensorineural deafness.^[25] The deafness is due to a reduction in the population and survival of melanoblast stem cells, which in addition to creating pigment-producing cells, develop into a variety of neurological cell types. White cats with one or two blue eyes have a particularly high likelihood of being deaf. Dominant white is distinct from albinism (c) which results from a mutation in a different gene that has no known impact on hearing.
• w^S (or S)=white spotting (
  tricolor cats), dominant allele. It only disrupts migration of melanocytes
  to certain patches in the skin, thus leading to the formation of white spots. It exhibits codominance and variable expression:
  • heterozygote (W^h or Ss)= high degree of spotting white (between 0–50% white); bicolor/tricolor or ventral white (usually the feet, nose, chest, and belly), which is dominant to solid color. Heterozygous cats have somewhere between 0-50% white.
  • heterozygote (W^l or SS)=low degree of spotting white (between 50 and 100% white); dominant harlequin and van pattern. The van pattern is named after the Lake Van region in Turkey, and expresses as coloration limited to the head and tail.
• w (or N)=wild-type or normal (non-white coats), recessive allele. Homozygotes for it won't have any white in their coat.
• w^g=Birman white gloving allele, recessive allele.^[23][26][27]

Colorpoint and albinism

The

• C is the wildtype allele resulting in full pigmentation and is completely dominant to all other known alleles at the locus.
• Point=c^s is the point allele associated with the Siamese colorpoint pattern.
• Sepia=c^b is an allele called sepia (or solid), and is most associated with Burmese cats. It produces a pattern similar to the Siamese colorpoint, but with a much lower contrast and amber-yellow to green eyes.
• Mink=c^s and c^b are codominant, with c^b/c^s cats having an intermediate phenotype termed mink,^[28] in which the pigment distribution is between sepia and point, and the eye color is blue-green (aquamarine).
• Albinism=c and c2 are two synonymous alleles recessive to all other alleles at the locus that cause albinism.^[29][30]
• c^m is a novel mutation in Burmese cats that results in a color pattern named mocha. Its interactions with other alleles have not yet been fully established.^[31]

The tyrosine pathway also produces neurotransmitters, thus mutations in the early parts of that pathway may affect not only pigment, but also neurological development. This results in a higher frequency of cross-eyes among colorpoint cats, as well as the high frequency of cross-eyes in white tigers.^[32]

• Comparison of different black (seal, sable) colourpoint cats
• 
  Black point Siamese
• 
  Black mink Tonkinese
• 
  Black sepia Burmese
• 
  Black blotched tabby (lynx) point cat
• 
  Black tortoiseshell point cat

Silver and golden series

Silver series

The silver series is caused by the Melanin inhibitor gene I/i. The dominant form causes melanin production to be suppressed, but it affects phaeomelanin (red pigment) much more than eumelanin (black or brown pigment). On tabbies, this turns the background a sparkling silver color while leaving the stripe color intact, making a cold-toned

• 
  Smoke
• 
  Shaded
• 
  Tipped (chinchilla / shell)
• 
  Cameo shaded (red / cream silver)

Golden series

If a cat has the wide band trait but no silver melanin inhibitor, the band will be golden instead of silver. These cats are known as golden tabbies, or in Siberian cats sunshine tabbies. The golden color is caused by the CORIN gene. Shaded golden and tipped golden are also possible, in the same hair length distribution as the silver-gene. However, there is no golden smoke, because the combination of wide band and nonagouti simply produces a solid cat.^{[34][unreliable source][35]}

Tipped or shaded cats

The genetics involved in producing the ideal tabby,

Likewise, poorly-expressed non-agouti or over-expression of melanin inhibitor will cause a pale, washed out black smoke. Various polygenes (sets of related genes), epigenetic factors, or modifier genes, as yet unidentified, are believed to result in different phenotypes of coloration, some deemed more desirable than others by fanciers.

The genetic influences on tipped or shaded cats are:

• Agouti gene.
• Tabby pattern genes (such as T^a masking the tabby pattern).
• Silver/melanin inhibitor gene I/i.
• Golden CORIN gene.
• Factors affecting the number and width of bands of color on each hair, such as the hypothetical wide band gene wb. Resulting in shaded or tipped (chinchilla/shell) pigmentation.
• Factors affecting the amount and quality of eumelanin and/or phaeomelanin pigment expression (such as theorized rufousing factors)
• Genes causing sparkling appearance (such as glitter in the Bengal, satin in the Tennessee Rex, grizzle in the Chausie).
• Factors to clear up residual striping (hypothetical Chaos, Confusion, Unconfused, Erase, and Roan factors).

• Silver series
• 
  Black silver spotted tabby Egyptian Mau.
• 
  Black smoke cat.
• 
  Cameo (red silver) shaded Maine Coon.
• 
  Black silver tipped (chinchilla) Persian cat.

• Golden series
• 
  Sunshine blotched tabby Siberian Cat.
• 
  Black golden ticked tabby British Shorthair.
• 
  Black golden ticked tabby British Shorthair.
• 
  Blue golden tipped (chinchilla) Persian cat.

Fever coat

Fever coat is an effect known in domestic cats, where a pregnant female cat has a fever or is stressed, causing her unborn kittens' fur to develop a silver-type color (silver-grey, cream, or reddish) rather than what the kitten's genetics would normally cause. After birth, over some weeks the silver fur is replaced naturally by fur colors according to the kitten's genetics.^[36][37][38]

Fur length and texture

Cat coat hair

Cat fur can be short, long, curly, or hairless. Most cats are short-haired, like their ancestor.

Most oriental breeds only express one single layer of silky coat.[39] However, cats can also have double-layered coats out of two hair types in which the down hairs form the soft, insulating undercoat, and the guard hairs form the protective outer coat.^[39]

A typical cat coat exists of all three natural hair types, but due to the equal lengths of two of these hairs, the coat is still considered double-layered.^[39] Typically, the down hairs comprise the undercoat while the guard and awn hairs make up the basic top coat.^[39][40] Double-coated cats with thick undercoats require daily grooming as these coats are more prone to matting.^[39] Double coats are found in for example the Persian, British Shorthair, Maine Coon and Norwegian Forest cat.

Additionally, there even exist cats which express all three natural types of cat hair in different lengths and structures, which form three different layers. These cats are called triple-coated. Siberians and Neva Masquerades are known for their unique triple coats,^[39] which provides double insulation to withstand their natural cold climate.

Coat mutations

There have been many genes identified that result in unusual cat fur. These genes were discovered in random-bred cats and selected for. Some of the genes are in danger of going extinct because the cats are not sold beyond the region where the mutation originated or there is simply not enough demand for cats expressing the mutation.

In many breeds, coat gene mutations are unwelcome. An example is the rex allele which appeared in Maine Coons in the early 1990s. Rexes appeared in America, Germany and the UK, where one breeder caused consternation by calling them "Maine Waves". Two UK breeders did test mating which indicated that this was probably a new rex mutation and that it was recessive. The density of the hair was similar to normally coated Maine Coons, but consisted only of down type hairs with a normal down type helical curl, which varied as in normal down hairs. Whiskers were more curved, but not curly. Maine Coons do not have awn hairs, and after moulting, the rexes had a very thin coat.^{[citation needed]}

Fur length

Cat fur length is governed by the Length gene in which the dominant form, L, codes for short hair, and the recessive l codes for long hair. In the longhaired cat, the transition from anagen (hair growth) to catagen (cessation of hair growth) is delayed due to this mutation.^[41] A rare recessive shorthair gene has been observed in some lines of Persian cat (silvers) where two longhaired parents have produced shorthaired offspring.

The Length gene has been identified as the

Curly-coated

There are various genes producing curly-coated or "rex" cats. New types of rex arise spontaneously in random-bred cats now and then. Some of the rex genes that breeders have selected for are:

• Devon Rex
  • Mutation in KRT71 (E1AB55), the same gene causing hairlessness in Sphynx cats. re is an allele completely recessive to the wildtype and completely dominant to hr found in Sphynx.^[43]
• Cornish Rex
  • Mutation in LPAR6 (A0A5F5XLZ8). A completely recessive allele termed r.^[44]
• Ural Rex
  • Mutation in LIPH.^[45]
• German Rex
  • Provisionally an allele termed gr. Same locus as Cornish, but proposed as a different allele. However, most breeders consider the German Rex to have r/r genotype.
• Oregon Rex (extinct)
  • A hypothetical recessive allele termed ro.
• Selkirk Rex
  • A dominant allele termed Se, although sometimes described as an incomplete dominant because the three possible allele pairings relate to three different phenotypes: heterozygous cats (Se/se) may have a fuller coat that is preferred in the show ring, while homozygous cats (Se/Se) may have a tighter curl and less coat volume. (se/se type cats have a normal coat.) This phenomenon may also colloquially be referred to as additive dominance.
• LaPerm
  • Provisional completely dominant Lp allele.

Hairlessness

There are also genes for hairlessness:

• h=French hairless cat,
  recessive
  .
• hd=British hairless cat,
  recessive
  .
• Hp=Russian Donskoy and Peterbald, dominant.
• hr=
  recessive. Identified on KRT71.^[43]

• The Wh gene (dominant, possibly incomplete) results in Wirehair cats. They have bent or crooked hair producing springy, crinkled fur.
• A hypothetical Yuc gene, or
  down hair
  production varies greatly between all breeds.
• A recessive autosomal gene for Onion hair which causes roughness and swelling on the hairs. The swelling is due to enlargement of the inner core of medulla cells.
• A recessive autosomal gene spf for sparse fur. As well as sparse coat, the hairs are thin, straggly and contorted and there is brown exudate around the eyes and nose and on the chest and stomach. A similar condition is linked to
  Ornithine Transcarbamylase Deficiency
  in mice.

Loci for coat colour, type and length

See also

References