Ovotransferrin
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Ovotransferrin (conalbumin) is a glycoprotein of egg white albumen.[1] Egg white albumen is composed of multiple proteins, of which ovotransferrin is the most heat reliable. It has a molecular weight of 76,000 daltons and contains about 700 amino acids. Ovotransferrin makes up approximately 13% of egg albumen (in contrast to ovalbumin, which comprises 54%).[2] As a member of the transferrin and metalloproteinase family, ovotransferrin has been found to possess antibacterial and antioxydant and immunomodulatory properties, arising primarily through its iron (Fe3+) binding capacity by locking away a key biochemical component necessary for micro-organismal survival. Bacteria starved of iron are rendered incapable of moving, making ovotransferrin a potent bacteriostatic.
Structure
Ovotransferrin is
The primary sequence of ovotransferrin is similar to that of many serum transferrins found in other species. Recently, scientists have discovered a blood serum transferrin in humans, that binds iron like ovotransferrin and which shows 50%
In addition, ovotransferrin is glycosylated by the N-linkage to the amino acid known as asparagine, meaning that the glycan, the carbohydrate chain, is attached to the nitrogen on the amino acid. Asparagine, found abundantly in asparagus (hence, its name), is one of twenty of the most common amino acids and was the first amino acid to be isolated. While ovotransferrin identifies with its family, there are two types of ovotransferrin proteins: apo and holo. Apo-Ovotransferrin is deprived of iron and holo-Ovotransferrin is saturated with iron. Because the apo-ovotransferrin is iron-deprived, it is easily destroyed by physical and chemical treatments.
Function and mechanism
Biologically, conalbumin isolates and sequesters metallic contaminants in the egg white.[3] Ovotransferrin is functionally and structurally analogous to mammalian lactoferrin[4] A recent study has shown superior performance of ovotransferrin when compared to lactoferrin in its capability to deliver iron without accumulation or inducing gastric irritability, rendering ovotransferrin as an excellent potential iron carrier for the treatment of Iron-deficiency anemia (IDA). Ovotransferrin showed superior physiological iron delivery over lactoferrin in a gastric barrier model. This data holds much promise for ovotransferrin's use in food supplements, with dual functionality as both antimicrobial and iron delivery mechanism.[5]
Role in disease and therapy
Numerous studies have identified dual anti-osteoporotic properties of ovotransferrin, both reducing bone resorption and promoting bone formation.[6] Beyond this, ovotransferrin shows promise as a drug carrier with potential applications in cancer treatment.[7] Indeed, ovotransferrin alone is toxic to cancer cells in-vitro. Its antioxidant and anti-inflammatory properties may also make ovotransferrin a viable treatment for cardiovascular disease.[8][9]
See also
References
- ^ "OVOTRANSFERRIN: The nutraceutical protein with antimicrobial, antioxidant and immunomodulatory properties". Bioseutica B.V.
- .
- ^ "Conalbumin". steadyhealth. Archived from the original on 2011-07-16.
- PMID 26556366.
- PMID 34829772.
- PMID 29502401.
- PMID 19886663.
- .
- PMID 28386310.
External links
- Conalbumin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)