Drug-induced urticaria

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Drug-induced urticaria
SpecialtyDermatology
Symptomsitching, burning, redness, and swelling
Usual onset1-24 hours after ingestion/application
Duration1-72 hours
Diagnostic methodThe onset of symptoms following the use of a medication.
TreatmentCan resolve without treatment, but may require anti-histamines or corticosteroids.

One of the most prevalent forms of adverse drug reactions is cutaneous reactions,[1] with drug-induced urticaria ranking as the second most common type, preceded by drug-induced exanthems.[2] Urticaria, commonly known as hives, manifests as weals, itching, burning, redness, swelling, and angioedema—a rapid swelling of lower skin layers, often more painful than pruritic. These symptoms may occur concurrently, successively, or independently. Typically, when a drug triggers urticaria, symptoms manifest within 24 hours of ingestion, aiding in the identification of the causative agent. Urticaria symptoms usually subside within 1–24 hours, while angioedema may take up to 72 hours to resolve completely.[2]

Mechanisms of drug-induced urticaria

Drug-induced urticaria occurs by immunologic and nonimmunologic mechanisms.[3] The primary mechanism for drug-induced urticaria involves a type-I hypersensitivity reaction mediated by IgE antibodies, commonly observed with ß-lactam use. This immune-mediated reaction necessitates a sensitization period, leading to more severe systemic reactions, including angioedema and anaphylaxis.[4]

Additionally, drug-induced urticaria can result from the activation of the complement cascade, a type-III hypersensitivity mediated by immune complexes. Complement cascade activation generates anaphylatoxins, releasing chemical mediators from basophils and mast cells, subsequently causing urticaria. This mechanism is seen in serum sickness and is associated with systemic symptoms such as fever, joint pain, and neurological symptoms.[4]

Some medications, like

COX-1 pathway, leading to increased production of leukotrienes, vasodilators implicated in edema and urticaria.[4] NSAIDs are the most common culprit of drug-induced urticaria and reactions to NSAIDs are often associated with angioedema.[5]

Topical medications, typically cause contact dermatitis, though can also induce urticaria through immune-mediated or non-immunological mechanisms. Antibiotics, often present in topical creams, are a common source of contact urticaria.[4]

Treatment and prevention

Patients experiencing drug-induced urticaria should avoid the causative drug if possible. When avoidance is not feasible, alternatives, such as using selective COX-2 inhibitors in place of typical NSAIDs, may be considered.

leukotriene antagonists can potentially prevent reactions in cases where avoidance or substitution is challenging.[6]

For post-exposure urticaria, discontinuation of the offending medication is crucial. Symptoms typically resolve upon removal of the causal agent, and management may involve anti-histamines or corticosteroids based on the severity of the reaction.[2]

List of medications known to cause urticaria

See also

References

  1. PMID 22052271
    .
  2. ^
    ISBN 978-3-031-09388-3
    , retrieved 2023-12-15
  3. ISBN 0-7216-2921-0
    .
  4. ^
    S2CID 37682452
    .
  5. ^
    S2CID 13759535
    .
  6. ^
    PMID 23535090
    .
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