Fastigial nucleus

Fastigial nucleus
Fastigial nucleus
	Cross-section of the cerebellum. Fastigial nucleus labeled at top-right.
Details
Identifiers
Latin	nucleus fastigii
NeuroNames	690
NeuroLex ID	birnlex_1146
TA98	A14.1.07.411
TA2	5840
FMA	72537
	Anatomical terms of neuroanatomy [edit on Wikidata]

The fastigial nucleus is located in the

nucleus globosus), and is grey matter embedded in the white matter

of the cerebellum.

It refers specifically to the concentration of gray matter nearest to the middle line at the anterior end of the superior

nucleus globosus

.

Although it is one dense mass, it is made up of two sections: the rostral fastigial nucleus and the caudal fastigial nucleus.

Structure

The

GABAergic synapses. The fastigial nucleus receives its input from Purkinje cells in the vermis. Most of its efferent connections travel via the inferior cerebellar peduncle to the vestibular nuclei, which are located at the junction of the pons and the medulla oblongata

.

The fastigial nucleus sends excitatory projections beyond the cerebellum. The likely neurotransmitters of fastigial nucleus

aspartate

.

Rostral fastigial nucleus

The rostral fastigial nucleus (rFN) is related to the vestibular system. It receives input from the vestibular nuclei and contributes to vestibular neuronal activity. The rFN interprets body motion and places it on spatial planes to estimate the movement of the body through space.^[2] It deals with antigravity muscle groups and other synergies involved with standing and walking.^[3]

Caudal fastigial nucleus

The caudal fastigial nucleus (cFN) is related to

saccadic eye movements. The Purkinje cell output from the oculomotor vermis relays through the cFN, where neurons directly related to saccadic eye movements are located.^[4]

References

This article incorporates text in the public domain from the 20th edition of Gray's Anatomy (1918)

Online Medical Dictionary entry

^ John K. Harting (1997). "The Global Cerebellum '97". University of Wisconsin Medical School. Retrieved 2007-06-28.
^ Brooks & Cullen, <http://www.jneurosci.org/content/29/34/10499.full.pdf> [Multimodal integration in rostral fastigial nucleus provides an estimate of body movement], 2009
^ James D. Geyer; Janice M. Keating; Daniel C. Potts (1998). Neurology for the Boards. Philadelphia: Lippincott-Raven. p. 9.
^ Kleine, Guan, & Buttner, <http://jn.physiology.org/content/90/5/3137.full.pdf+html> [Saccade-related neurons in the primate fastigial nucleus: what do they encode?], 2003

External links

Illustration and text: cere/text/P5/fastig.htm at the University of Wisconsin-Madison Medical school
https://web.archive.org/web/20150621011739/http://www.mona.uwi.edu/fpas/courses/physiology/neurophysiology/Cerebellum.htm
https://web.archive.org/web/20080405062814/http://www.lib.mcg.edu/edu/eshuphysio/program/section8/8ch6/s8ch6_29.htm
NIF Search - Fastigial Nucleus via the Neuroscience Information Framework

[1] John K. Harting (1997). "The Global Cerebellum '97". University of Wisconsin Medical School. Retrieved 2007-06-28.

[2] Brooks & Cullen, <http://www.jneurosci.org/content/29/34/10499.full.pdf> [Multimodal integration in rostral fastigial nucleus provides an estimate of body movement], 2009

[3] James D. Geyer; Janice M. Keating; Daniel C. Potts (1998). Neurology for the Boards. Philadelphia: Lippincott-Raven. p. 9.

[4] Kleine, Guan, & Buttner, <http://jn.physiology.org/content/90/5/3137.full.pdf+html> [Saccade-related neurons in the primate fastigial nucleus: what do they encode?], 2003

[2]

[3]

[4]

1° :		Cuneate nucleus
2° :	→ Posterior external arcuate fibers, Internal arcuate fibers) → Medial lemniscus/Trigeminal lemniscus → Thalamus (VPL, VPM )
3° :	→ Posterior limb of internal capsule → Postcentral gyrus

Fast/lateral	1° ( Anterior Spinothalamic tract → Spinal lemniscus → VPL of Thalamus) → 3° (Postcentral gyrus) → 4° (Posterior parietal cortex ) 2° ( Midbrain tectum )
Slow/medial	1° (Group C nerve fiber → Spinoreticular tract → Reticular formation) → 2° (MD of Thalamus) → 3° (Cingulate cortex)