Frank's sign
Frank's sign is a diagonal crease in the ear lobe extending from the
It has been hypothesised that Frank's sign is indicative of
premature aging and the loss of dermal and vascular fibers has also been hypothesized.[8] Some studies have focused on association between bilateral earlobe crease and coronary artery disease.[9] It is probably prudent to consider Frank's Sign alongside other clinical markers of physiological ageing, rather than utilising it as a stand-alone sign in the identification of coronary artery disease.[10]
Severity
- Grade 3 – A deep crease across the whole of the earlobe.
- Grade 2b – Creased more than halfway across the earlobe.
- Grade 2a – A superficial crease across the earlobe.
- Grade 1 – A small amount of wrinkling on the earlobe.[11]
Notable individuals with Frank's sign
References
- ^ PMID 4718047.
- .
- ^ Miot, H.A., Molina de Medeiros, M. etal (2006). Association between coronary artery disease and the diagonal earlobe an preauricular creases in men. Anais Brasileiros de Dermatologia. vol.81 no.1
- ^ Mustafa Ahmed, M.D. (13 August 2014). "Earlobe Crease And Heart Disease – Fact Or Myth?". Abel Healthcare. Retrieved 8 February 2015.
- PMID 3827155.
- PMID 11108067.
- PMID 28460854.
- PMID 24597888.
- S2CID 26858693.
- PMID 28946988.
- ^ "Frank's Sign – Diagonal earlobe crease (DELC)". Stanford Medicine. July 2, 2015. Retrieved January 1, 2021.
- ^ Livingston, David (November 29, 2018). "Dick Van Dyke (age 92), Premiere Of Disney's 'Mary Poppins Returns' - Arrivals". gettyimages.com. Getty Images. Retrieved November 30, 2018.
- ^ a b Lindsay, Jessica (March 27, 2018). "If you have this mark on your ear, it could be a warning you have heart disease". Metro. Retrieved January 1, 2021.
- ^ Wachs, Daliah (August 29, 2018). "Deep Forehead Wrinkles May Suggest Heart Disease Risk". KDWN. Retrieved January 1, 2021.