Glutamate formimidoyltransferase
| Formiminotransferase domain, N-terminal subdomain | |||||||||
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| Formiminotransferase domain | |||||||||
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Glutamate formimidoyltransferase is a
tetrahydrofolate as part of histidine catabolism
. It catalyses two reactions:
- tetrahydrofolate + N-formimidoyl-L-glutamate
- 5-formyltetrahydrofolate + L-glutamate <=> tetrahydrofolate + N-formyl-L-glutamate
It is classified under EC 2.1.2.5 and in mammals is found as part of a bifunctional enzyme that also has formimidoyltetrahydrofolate cyclodeaminase activity.[1]
Structure
The formiminotransferase (FT)
substrate is predicted to form a number of contacts with residues found in both the N-terminal and C-terminal subdomains.[2] In humans, deficiency of this enzyme results in a disease phenotype.[3]
References
External links
- Glutamate+formimidoyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
