Host modulatory therapy
Host modulatory therapy is an emerging treatment concept in the management of
Host modulatory therapy is a means of treating the host's side of the
Agents
- Non steroidal Anti Inflammatory Drugs
They inhibit prostaglandin E2 formation (PGE2) that is produced by neutrophils, fibroblasts and gingival epithelial cells in response to bacteria. PGE2 upregulates bone resorption by osteoclasts and their levels are higher in patients with periodontal disease than in healthy individuals.[2]
- Bisphosphonate
- Sub antimicrobial doxycycline[3]
Sub antimicrobial doxycycline is 20 mg doxycycline (Periostat) approved and indicated as an adjunct to SRP in the treatment of chronic periodontitis. It is given twice daily for three months for a maximum of nine months. This dosage of doxycycline has cytokine and osteoclasts inhibitory action rather than being antimicrobial.
These agents not only help improve wound healing but also stimulate regeneration of the lost bone,
References
- ISBN 978-1-4557-0638-9. Retrieved 1 April 2013.
- ^ "Osteoclasts - Wheeless' Textbook of Orthopaedics". Wheelessonline.com. 2012-06-01. Retrieved 2015-05-06.
- ^ "Subantimicrobial Dose Doxycycline — Host Modulation in the Treatment of Periodontitis" (PDF). Oralscience.ca. Retrieved 2015-05-06.
- PMID 18710336.