Fusobacterium nucleatum

Source: Wikipedia, the free encyclopedia.
See also: Chronic periodontitis

Fusobacterium nucleatum
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Fusobacteriota
Class: Fusobacteriia
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Species:
F. nucleatum
Binomial name
Fusobacterium nucleatum
Knorr, 1922

Fusobacterium nucleatum is a

oral cavity, that plays a role in periodontal disease. This organism is commonly recovered from different monocultured microbial and mixed infections in humans and animals. In health and disease, it is a key component of periodontal plaque due to its abundance and its ability to coaggregate with other bacteria species in the oral cavity.[1][2]

Preterm births

Research implicates periodontal disease caused by F. nucleatum with

vaginal microbiome, especially in women with a condition known as bacterial vaginosis.[4] Both F. nucleatum vaginal colonization and bacterial vaginosis also have been linked with preterm birth and infections within the uterus.[5] Thus, preterm birth arising by infections caused by F. nucleatum could also arise from invasive infection into the uterine tissue originating from the colonized vagina.[citation needed
]

Colon cancer

F. nucleatum has a demonstrated association with

E-cadherins via a FadA, an outer membrane protein.[7] Additionally, a surface expressed lectin called Fap2 mediates F. nucleatum adherence to colorectal cancer cells that express Gal/GalNAc moieties on their surface. Binding via Fap2 has also been shown to up-regulate production of cytokines associated with higher rates of metastasis.[8]

Natural competence

Type IV pili facilitate natural competence in F. nucleatum[9]. Natural competence involves three principal stages: (1) Uptake of exogenous DNA and transport to the cytoplasm, (2) homologous DNA that has been taken up can integrate into the recipient cell genome by homologous recombination, and (3) the integrated exogenous DNA can express gene functions[9].

See also

References

  1. PMID 11889109
    .
  2. doi:10.21775/cimb.013.025
    .
  3. PMID 15039352
    .
  4. PMID 8324131
    .
  5. S2CID 345396
    .
  6. PMID 23954159
    .
  7. PMID 32993749
    .
  8. S2CID 213030137. Retrieved 2022-07-18. {{cite journal}}: Cite journal requires |journal= (help
    )
  9. ^ a b Sanders BE, Umaña A, Nguyen TTD, Williams KJ, Yoo CC, Casasanta MA, Wozniak B, Slade DJ. Type IV pili facilitated natural competence in Fusobacterium nucleatum. Anaerobe. 2023 Aug;82:102760. doi: 10.1016/j.anaerobe.2023.102760. Epub 2023 Jul 13. PMID: 37451427

External links

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