Joseph DeRisi

Edit links
Source: Wikipedia, the free encyclopedia.
Joseph DeRisi
NationalityAmerican
Alma materStanford University, University of California, Santa Cruz
Known forViroChip, work on identifying SARS virus, gene expression in Plasmodium falciparum
Scientific career
FieldsBiology
InstitutionsUniversity of California, San Francisco Howard Hughes Medical Institute
ThesisThe Analysis of whole genome gene expression in the budding yeast Saccharomyces cerevisiae. (1999)
Doctoral advisorPatrick O. Brown

Joseph Lyman DeRisi is an American biochemist, specializing in molecular biology, parasitology, genomics, virology, and computational biology.

Early life and education

DeRisi was raised in Carmichael, California, where he graduated from Del Campo High School.[1] He received a B.A. in Biochemistry and Molecular Biology in 1992 from the University of California, Santa Cruz.[2]

DeRisi earned his Ph.D. in biochemistry from

University of California San Francisco.[2][6]

Career and research

DeRisi has been a faculty member of the UCSF biochemistry and biophysics department since 1999. As of 2022 he is a professor of biochemistry and biophysics and is also the director of UCSF's Sandler Program for Breakthrough Biomedical Research.[2][6]

DeRisi is known for printing the first whole-genome expression array,[7] performing the first broad analysis of differential gene expression in cancer cells,[8] profiling gene expression throughout the lifecycle of the malaria-causing protozoan Plasmodium falciparum,[9] genomic characterization of the SARS-CoV-1 virus,[10] and pioneering virus discovery using gene hybridization arrays and DNA sequencing technologies.[11]

In his early career, DeRisi was a pioneer of

open access publishing.[12]

In 2002, DeRisi and his research collaborator David Wang developed the ViroChip, a DNA microarray that could be used to rapidly identify viruses in a sample of blood or tissue.

SARS-CoV-1 virus in 2003. In 2004, DeRisi was named a MacArthur fellow for his work with ViroChip and genomic diagnostic techniques.[12][14]

DeRisi became a Howard Hughes Medical Institute (HHMI) investigator in 2005, and received financial support from HHMI for his research.[6][15] He remained an investigator until 2016.[16]

DeRisi and his colleagues employ metagenomic next-generation sequencing (mNGS) for applications including to identify the causal agents in cases of infectious encephalitis and meningitis and to discriminate between autoimmune and infectious causes, diagnosing cases that are difficult to decipher using traditional clinical laboratory techniques.

Don Ganem, have identified a parasite, Nosema ceranae, that appears to be responsible for colony collapse among honeybees.[19] He has also de-bunked the relation of viruses to certain subsets of human cancer.[20]

DeRisi and his colleague Dr. Michael Wilson used a

autoantigen that is the cause of the symptoms.[20][21]

DeRisi’s lab at UCSF also conducts research to understand the genetics of the malaria-causing pathogen Plasmodium falciparum, the causative agent of the most deadly form of human malaria.[12][22] DeRisi's group has developed candidate drugs to cure malaria.[23] In 2011, the group determined the function of the apicoplast, a unique organelle in apicomplexans, identifying the target of an anti-malarial drug that was a preclinical candidate.[24][25]

In 2016, DeRisi became the co-president of the newly established

CZ Biohub, alongside Stephen Quake.[26] After joining CZ Biohub, DeRisi established a team of developers to create a cloud-based metagenomic diagnostic platform based on code from his lab at UCSF. The platform, then named IDSeq, was initially launched for testing by a small group in 2018.[27][17] The development and computing costs were backed by the Chan Zuckerberg Initiative and CZ Biohub.[17] The platform is used to rapidly identify pathogens from metagenomic sequencing data,[28] and as of 2022 is known as CZ-ID.[29]

In 2020, early in the COVID-19 pandemic, DeRisi led a team that turned an empty lab space adjacent to the CZ Biohub into a CLIA-certified COVID-19 testing facility in eight days.[30][31] CLIAhub became one of the nation's leading COVID-19 testing centers, processing thousands of tests per day and becoming a model for the nation.[32][33][34] DeRisi’s early warning of the pandemic and development of rapid testing technology was documented by Michael Lewis in his book The Premonition: A Pandemic Story.[35][36] At the same time, DeRisi became an active proponent of developing a national COVID-19 surveillance system to identify and monitor mutations in the COVID-19 virus.[37][38][33]

Awards and honors

And Membership in scientific organizations would contain:

References

  1. ^ "Dr. Joe Derisi". San Juan Education Foundation. Retrieved 2022-10-17.
  2. ^ a b c d "Sandler Program for Breakthrough Biomedical Research: Our Leadership". UCSF Sandler Program for Breakthrough Biomedical Research. Retrieved 2022-10-28.
  3. OCLC 80580640
    . Retrieved 2022-10-18.
  4. ^ a b Kahn, Jennifer (2006-12-02). "New Chips on the Block" (PDF). The Economist Technology Quarterly. Retrieved 2022-10-12.
  5. ^ a b Adams, Amy. "PhD alum Joe DeRisi brings innovation to the masses". Stanford Medicine Magazine. Vol. Summer 2002. Retrieved 2022-10-18.
  6. ^ a b c Hopkin, Karen (2005-11-20). "SARS, Malaria, and the Microarray". The Scientist Magazine. Retrieved 2022-10-17.
  7. PMID 9381177
    .
  8. S2CID 23091561
    .
  9. PMID 16493140
  10. PMID 12730500
  11. PMID 12429852
    .
  12. ^ a b c Russell, Sabin (2004-09-28). "THE MACARTHUR GRANTS: BAY AREA PROFILES / His quick work on SARS gave crucial answers". SF Gate. Retrieved 2022-10-28.
  13. ^
    ISSN 0362-4331
    . Retrieved 2022-10-12.
  14. ^ "Joseph DeRisi". Macarthur Foundation. Retrieved 2022-11-01.
  15. ^ O'Brien, Jennifer (2005-03-22). "Two UCSF Scientists Named Howard Hughes Medical Institute Investigators | UC San Francisco". UCSF. Retrieved 2022-10-31.
  16. ^ "Joseph L. DeRisi" (Text). HHMI. Retrieved 2022-10-31.
  17. ^ a b c Yong, Ed (2018-10-16). "A Simpler Way to Get to the Bottom of Mysterious Illnesses in Poor Countries". The Atlantic. Retrieved 2022-11-01.
  18. PMID 31269365
    .
  19. ^ "UCSF Sleuths Identify Suspects in Mystery of Vanishing Honeybees". UCSF.com. 25 April 2007. Retrieved October 28, 2022.
  20. ^ a b Allday, Erin (July 15, 2019). "Rare disease discovery: Antibodies fighting cancer go on to attack brain". sfchronicle.com. Retrieved May 1, 2021.
  21. PMID 31269365
    . Retrieved 2022-11-01.
  22. ISSN 0362-4331
    . Retrieved 2022-11-01.
  23. PMID 25453091
    .
  24. ^ Palca, Joe (2011-08-30). "A Remnant From Algae In Malaria Parasite May Prove Its Weakness". NPR. Retrieved 2022-11-01.
  25. PMID 21912516
    .
  26. S2CID 221637469
    .
  27. ISSN 1059-1028
    . Retrieved 2022-11-01.
  28. PMID 33057676
    .
  29. PMID 35803954
    .
  30. ^ "A Model for the Nation: Building a COVID-19 Testing Lab in Only Eight Days". chanzuckerberg.com. October 21, 2020. Retrieved May 1, 2021.
  31. ^ Lewis, Michael (April 16, 2020). "The Covid Test Lab That Could Save America". bloomberg.com. Retrieved May 1, 2021.
  32. ^ Lewis, Michael (May 8, 2020). "Armed With Swabs, Covid Hunters Stalk Their Prey". bloomberg.com. Retrieved May 1, 2021.
  33. ^ a b Lewis, Michael (June 21, 2020). "The New Weapon in the Covid-19 War". bloomberg.com. Retrieved May 1, 2021.
  34. ^ Lewis, Michael (April 7, 2020). "In Berkeley, Hunting Toilet Paper and Dodging Hikers". bloomberg.com. Retrieved May 1, 2021.
  35. ISSN 0362-4331
    . Retrieved 2022-11-01.
  36. ISSN 0261-3077
    . Retrieved 2022-11-01.
  37. ^ Dunn, Lauren (January 8, 2021). "As U.K. variant spreads in U.S., scientists warn that country isn't doing enough to track Covid strains". NBCNews.com. Retrieved May 1, 2021.
  38. ^ Allday, Erin (January 23, 2021). "The inside story of how the Bay Area coronavirus variant was discovered". sfchronicle.com. Retrieved May 1, 2021.
  39. ^ "John J. Carty Award for the Advancement of Science". National Academy of Sciences. 2014. Retrieved 2022-11-18.
  40. ^ "California Academy of Sciences Welcomes New Fellows, Bestows Annual Awards". calacademy.org. October 4, 2013. Retrieved May 1, 2021.
  41. ^ "65 Fellows Elected into the American Academy of Microbiology". asm.org. February 16, 2021. Retrieved May 1, 2021.
  42. ^ "Joseph L. DeRisi". American Academy of Arts & Sciences. Retrieved 2022-11-18.
  43. ^ National Academy of Sciences Members and Foreign Associates Elected, News from the National Academy of Sciences, National Academy of Sciences, May 3, 2016, archived from the original on May 6, 2016, retrieved 2016-05-14.
  44. ^ Bai, Nina (October 17, 2016). "3 UCSF Faculty Elected to the National Academy of Medicine for 2016". ucsf.edu. Retrieved May 1, 2021.

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Joseph_DeRisi&oldid=1220683964"