KLK8
| KLK8 | |||
|---|---|---|---|
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 19: 51 – 51 Mb | Chr 7: 43.45 – 43.45 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.[5][6][7][8][9]
Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000129455 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064023 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 10102990.
- PMID 9714609.
- S2CID 436200.
- S2CID 83910246.
- ^ a b "Entrez Gene: KLK8 kallikrein-related peptidase 8".
Further reading
- Underwood LJ, Tanimoto H, Wang Y, et al. (1999). "Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma". Cancer Res. 59 (17): 4435–9. PMID 10485494.
- Harvey TJ, Hooper JD, Myers SA, et al. (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4". J. Biol. Chem. 275 (48): 37397–406. PMID 10969073.
- Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. PMID 11054574.
- Magklara A, Scorilas A, Katsaros D, et al. (2001). "The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer". Clin. Cancer Res. 7 (4): 806–11. PMID 11309326.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. PMID 12975309.
- Cané S, Bignotti E, Bellone S, et al. (2004). "The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer". Am. J. Obstet. Gynecol. 190 (1): 60–6. PMID 14749636.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. PMID 15057824.
- Shigemasa K, Tian X, Gu L, et al. (2004). "Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer". Oncol. Rep. 11 (6): 1153–9. PMID 15138549.
- Li Y, Qian YP, Yu XJ, et al. (2005). "Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory". Mol. Biol. Evol. 21 (11): 2111–5. PMID 15282331.
- Rajapakse S, Ogiwara K, Takano N, et al. (2006). "Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins". FEBS Lett. 579 (30): 6879–84. S2CID 22439153.
- Kishi T, Cloutier SM, Kündig C, et al. (2006). "Activation and enzymatic characterization of recombinant human kallikrein 8" (PDF). Biol. Chem. 387 (6): 723–31. S2CID 19299456.
- Sher YP, Chou CC, Chou RH, et al. (2007). "Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness". Cancer Res. 66 (24): 11763–70. PMID 17178872.
- Lu ZX, Peng J, Su B (2007). "A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory". Hum. Mutat. 28 (10): 978–84. S2CID 6001199.
External links
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |