Matrix Gla protein
| MGP | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 12: 14.88 – 14.89 Mb | Chr 6: 136.85 – 136.85 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Matrix Gla protein (MGP) is member of a family of
MGP is found in a number of body
It is present in bone together with the related vitamin K2-dependent protein osteocalcin. In bone, its production is increased by vitamin D.
Genetics
The MGP was linked to the short arm of
Physiology
MGP and osteocalcin are both calcium-binding proteins that may participate in the organisation of bone tissue. Both have
Role in disease
Abnormalities in the MGP gene have been linked with Keutel syndrome, a rare condition characterised by abnormal calcium deposition in cartilage, peripheral stenosis of the pulmonary artery, and midfacial hypoplasia.[10]
Mice that lack MGP develop to term but die within two months as a result of
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000111341 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030218 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 23852538.
- ^ S2CID 4335985.
- PMID 12667547.
- PMID 2394711.
- ^ "Sequence: M58549.1 : Human matrix Gla protein (MGP) mRNA, complete cds". European Nucleotide Archive. European Bioinformatics Institute.
- S2CID 1244954.
External links
- matrix+Gla+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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