ORC1
| ORC1 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 1: 52.37 – 52.4 Mb | Chr 4: 108.44 – 108.47 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene.[5][6] It is closely related to CDC6, and both are the same protein in archaea.[7]
Function
The
MYST histone acetyltransferase 2 (MYST2/HBO1), a protein involved in control of transcription silencing.[6]
Interactions
ORC1 has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000085840 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028587 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8884289.
- ^ a b "Entrez Gene: ORC1L origin recognition complex, subunit 1-like (yeast)".
- PMID 28146124.
- ^ PMID 12614612.
- PMID 9566895.
- ^ PMID 11931757.
- PMID 10438470.
- PMID 11779870.
- PMID 11323433.
Further reading
- Gavin KA, Hidaka M, Stillman B (Dec 1995). "Conserved initiator proteins in eukaryotes". Science. 270 (5242): 1667–71. S2CID 43633493.
- Ohtani K, DeGregori J, Leone G, Herendeen DR, Kelly TJ, Nevins JR (Dec 1996). "Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor". Molecular and Cellular Biology. 16 (12): 6977–84. PMID 8943353.
- Saha P, Chen J, Thome KC, Lawlis SJ, Hou ZH, Hendricks M, Parvin JD, Dutta A (May 1998). "Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase". Molecular and Cellular Biology. 18 (5): 2758–67. PMID 9566895.
- Iizuka M, Stillman B (Aug 1999). "Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein". The Journal of Biological Chemistry. 274 (33): 23027–34. PMID 10438470.
- Jiang W, McDonald D, Hope TJ, Hunter T (Oct 1999). "Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication". The EMBO Journal. 18 (20): 5703–13. PMID 10523313.
- Tatsumi Y, Tsurimoto T, Shirahige K, Yoshikawa H, Obuse C (Feb 2000). "Association of human origin recognition complex 1 with chromatin DNA and nuclease-resistant nuclear structures". The Journal of Biological Chemistry. 275 (8): 5904–10. PMID 10681582.
- Thome KC, Dhar SK, Quintana DG, Delmolino L, Shahsafaei A, Dutta A (Nov 2000). "Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins". The Journal of Biological Chemistry. 275 (45): 35233–41. PMID 10954718.
- Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. PMID 11323433.
- Laman H, Peters G, Jones N (Dec 2001). "Cyclin-mediated export of human Orc1". Experimental Cell Research. 271 (2): 230–7. PMID 11716535.
- Fujita M, Ishimi Y, Nakamura H, Kiyono T, Tsurumi T (Mar 2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells". The Journal of Biological Chemistry. 277 (12): 10354–61. PMID 11779870.
- Ladenburger EM, Keller C, Knippers R (Feb 2002). "Identification of a binding region for human origin recognition complex proteins 1 and 2 that coincides with an origin of DNA replication". Molecular and Cellular Biology. 22 (4): 1036–48. PMID 11809796.
- Méndez J, Zou-Yang XH, Kim SY, Hidaka M, Tansey WP, Stillman B (Mar 2002). "Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication". Molecular Cell. 9 (3): 481–91. PMID 11931757.
- Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. PMID 12614612.
- Ohta S, Tatsumi Y, Fujita M, Tsurimoto T, Obuse C (Oct 2003). "The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle". The Journal of Biological Chemistry. 278 (42): 41535–40. PMID 12909626.
- Tatsumi Y, Ohta S, Kimura H, Tsurimoto T, Obuse C (Oct 2003). "The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1". The Journal of Biological Chemistry. 278 (42): 41528–34. PMID 12909627.
- Abdurashidova G, Danailov MB, Ochem A, Triolo G, Djeliova V, Radulescu S, Vindigni A, Riva S, Falaschi A (Aug 2003). "Localization of proteins bound to a replication origin of human DNA along the cell cycle". The EMBO Journal. 22 (16): 4294–303. PMID 12912926.
- Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J (Jul 2004). "Self-assembling protein microarrays". Science. 305 (5680): 86–90. S2CID 20936301.
- Lidonnici MR, Rossi R, Paixão S, Mendoza-Maldonado R, Paolinelli R, Arcangeli C, Giacca M, Biamonti G, Montecucco A (Oct 2004). "Subnuclear distribution of the largest subunit of the human origin recognition complex during the cell cycle". Journal of Cell Science. 117 (Pt 22): 5221–31. PMID 15454574.