POLD2
| POLD2 | ||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ||||||||||||||||||||||||||||||||||||||||
| Wikidata | ||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||
DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene.[5][6] It is a component of the DNA polymerase delta complex.
Interactions
POLD2 has been shown to
PCNA.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000106628 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020471 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8530069.
- ^ "Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa".
- PMID 11986310.
Further reading
- Hindges R, Hübscher U (1997). "Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2)". Genomics. 44 (1): 45–51. PMID 9286699.
- Hisama FM, Chen YH, Meyn MS, Oshima J, Weissman SM (2000). "WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts". Cancer Res. 60 (9): 2372–6. PMID 10811112.
- Mo J, Liu L, Leon A, Mazloum N, Lee MY (2000). "Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA". Biochemistry. 39 (24): 7245–54. PMID 10852724.
- Perez A, Leon A, Lee MY (2000). "Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta". Biochim. Biophys. Acta. 1493 (1–2): 231–6. PMID 10978529.
- Szekely AM, Chen YH, Zhang C, Oshima J, Weissman SM (2000). "Werner protein recruits DNA polymerase δ to the nucleolus". Proc. Natl. Acad. Sci. U.S.A. 97 (21): 11365–70. PMID 11027336.
- He H, Tan CK, Downey KM, So AG (2001). "A tumor necrosis factor α- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase δ and proliferating cell nuclear antigen". Proc. Natl. Acad. Sci. U.S.A. 98 (21): 11979–84. PMID 11593007.
- Lu X, Tan CK, Zhou JQ, You M, Carastro LM, Downey KM, So AG (2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol. Chem. 277 (27): 24340–5. PMID 11986310.
- Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. PMID 12171929.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J. Biol. Chem. 278 (12): 10041–7. PMID 12522211.
- Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. PMID 12690205.
- Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. PMID 15231747.
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
- Tsurimoto T, Shinozaki A, Yano M, Seki M, Enomoto T (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta". Genes Cells. 10 (1): 13–22. S2CID 24977510.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. S2CID 4427026.
External links
- Overview of all the structural information available in the PDB for UniProt: P49005 (Human DNA polymerase delta subunit 2 (POLD2)) at the PDBe-KB.
 | This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it. |