CDC25A
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| Location (UCSC) | Chr 3: 48.16 – 48.19 Mb | Chr 9: 109.7 – 109.72 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.
Function
CDC25A is a member of the CDC25 family of dual-specificity phosphatases.
Dual-specificity protein
tyrosine phosphatase family (as opposed to the serine/threonine phosphatase
family).
All mammals examined to date have three homologues of the ancestral Cdc25 gene (found e.g. in the fungus species S. pombe), designated Cdc25A, Cdc25B, and Cdc25C. In contrast, some invertebrates harbour two (e.g., the Drosophila proteins String and Twine) or four (e.g., C. elegans Cdc-25.1 - Cdc-25.4) homologues. CDC25A is required for progression from G1 to the S phase of the
Cdc2
(Cdk1), the principal mitotic Cdk.
Involvement in cancer
CDC25A is specifically degraded in response to
CDKs
.
CDC25A is considered an RAS to transform rodent fibroblasts, and it is overexpressed in tumours from a variety of tissues, including breast and head & neck tumours. It is a target of the E2F family of transcription factors. Therefore, its overexpression is a common consequence of dysregulation of the p53-p21-Cdk axis in carcinogenesis.[5]
Interactions
CDC25A has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164045 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032477 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: CDC25A cell division cycle 25 homolog A (S. pombe)".
- PMID 11416155.
- PMID 7744247.
- PMID 9230211.
- PMID 12963847.
- PMID 9278511.
- PMID 12399544.
- PMID 18480045.
- PMID 9891079.
- PMID 8617791.
- PMID 11912208.
- PMID 10373478.
- PMID 7644510.
External links
- Human CDC25A genome location and CDC25A gene details page in the UCSC Genome Browser.
Further reading
- Parsons R (1998). "Phosphatases and tumorigenesis". Current Opinion in Oncology. 10 (1): 88–91. S2CID 33899887.
- Kerkhoff E, Rapp UR (1998). "Cell cycle targets of Ras/Raf signalling". Oncogene. 17 (11 Reviews): 1457–62. S2CID 19673633.
- Nilsson I, Hoffmann I (2000). "Cell cycle regulation by the Cdc25 phosphatase family". Progress in Cell Cycle Research. Vol. 4. pp. 107–14. PMID 10740819.
- Galaktionov K, Beach D (1992). "Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins". Cell. 67 (6): 1181–94. S2CID 9659637.
- Conklin DS, Galaktionov K, Beach D (1995). "14-3-3 proteins associate with cdc25 phosphatases". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7892–6. PMID 7644510.
- Galaktionov K, Lee AK, Eckstein J, Draetta G, Meckler J, Loda M, Beach D (1995). "CDC25 phosphatases as potential human oncogenes". Science. 269 (5230): 1575–7. PMID 7667636.
- Galaktionov K, Jessus C, Beach D (1995). "Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation" (PDF). Genes Dev. 9 (9): 1046–58. PMID 7744247.
- Demetrick DJ, Beach DH (1994). "Chromosome mapping of human CDC25A and CDC25B phosphatases". Genomics. 18 (1): 144–7. PMID 8276402.
- Xu X, Burke SP (1996). "Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25". J. Biol. Chem. 271 (9): 5118–24. PMID 8617791.
- Tiefenbrun N, Melamed D, Levy N, Resnitzky D, Hoffman I, Reed SI, Kimchi A (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. PMID 8668211.
- Huang TS, Shu CH, Yang WK, Whang-Peng J (1997). "Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced apoptosis". Cancer Res. 57 (14): 2974–8. PMID 9230211.
- Fauman EB, Cogswell JP, Lovejoy B, Rocque WJ, Holmes W, Montana VG, Piwnica-Worms H, Rink MJ, Saper MA (1998). "Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A". Cell. 93 (4): 617–25. S2CID 5762201.
- Coqueret O, Bérubé G, Nepveu A (1998). "The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phase". EMBO J. 17 (16): 4680–94. PMID 9707427.
- Iavarone A, Massagué J (1999). "E2F and Histone Deacetylase Mediate Transforming Growth Factor β Repression of cdc25A during Keratinocyte Cell Cycle Arrest". Mol. Cell. Biol. 19 (1): 916–22. PMID 9858615.
- Sexl V, Diehl JA, Sherr CJ, Ashmun R, Beach D, Roussel MF (1999). "A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2". Oncogene. 18 (3): 573–82. PMID 9989807.
- Mochizuki T, Kitanaka C, Noguchi K, Muramatsu T, Asai A, Kuchino Y (1999). "Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway". J. Biol. Chem. 274 (26): 18659–66. PMID 10373478.
- Xia K, Lee RS, Narsimhan RP, Mukhopadhyay NK, Neel BG, Roberts TM (1999). "Tyrosine Phosphorylation of the Proto-Oncoprotein Raf-1 Is Regulated by Raf-1 Itself and the Phosphatase Cdc25A". Mol. Cell. Biol. 19 (7): 4819–24. PMID 10373531.
- Vigo E, Müller H, Prosperini E, Hateboer G, Cartwright P, Moroni MC, Helin K (1999). "CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase". Mol. Cell. Biol. 19 (9): 6379–95. PMID 10454584.
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