PTPN6
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| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 12: 6.95 – 6.96 Mb | Chr 6: 124.7 – 124.72 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene.[5]
Function
The protein encoded by this gene is a member of the
SHP-1 pathway). Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.[6]
Expression
SHP-1 gene has two
epithelial cells and high in hemopoietic cells. SHP-1 level in epithelial cells increases and in hematopoietic cells decreases in cancer.[7]
Interactions
PTPN6 has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000111679 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004266 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1639416.
- ^ "Entrez Gene: PTPN6 protein tyrosine phosphatase, non-receptor type 6".
- S2CID 33833067.
- S2CID 42228230.
- PMID 9528781.
- PMID 7684496.
- PMID 9890995.
- PMID 11551923.
- PMID 10228003.
- PMID 8627166.
- PMID 11356834.
- S2CID 31471121.
- PMID 9774457.
- PMID 10835420.
- PMID 7673163.
- PMID 9733788.
- S2CID 16866005.
- PMID 12051764.
- ^ PMID 10747947.
- PMID 8632004.
- PMID 11964172.
- PMID 12145285.
- PMID 8943354.
- PMID 10772872.
- ^ PMID 10660620.
- PMID 11160222.
- PMID 10903717.
- PMID 9285412.
- PMID 10764762.
- PMID 9842885.
- PMID 9531263.
- PMID 9973385.
- PMID 10617656.
- PMID 11294838.
- PMID 8114715.
- PMID 9765283.
- PMID 8760799.
- PMID 11723252.
- PMID 10521452.
- PMID 11266449.
- PMID 10660565.
- PMID 10072516.
- PMID 7629131.
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