PTPRN2
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Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) also known as islet cell autoantigen-related protein (ICAAR) and phogrin is an
insulin-dependent diabetes mellitus.[7]
Function
Due to a close similarity in the gene sequences, the
membrane trafficking
.
The protein produced by PTPRN2 possesses an
catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN, also known as IA-2.[7]
Gene
Three
transcript variants of this gene, which encode distinct proteins, have been reported.[7]
Interactions
PTPRN2 has been shown to
UBQLN4.[11]
Clinical significance
R-PTP-N2 functions as an
References
- ^ a b c ENSG00000282185 GRCh38: Ensembl release 89: ENSG00000155093, ENSG00000282185 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056553 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8954911.
- PMID 9220540.
- ^ a b c d "Entrez Gene: PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2".
- PMID 20097759.
- PMID 12421765.
- PMID 11086001.
- S2CID 13709685.
- PMID 8637868.
- S2CID 5392803.
Further reading
- Lan MS, Lu J, Goto Y, Notkins AL (1994). "Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma". DNA Cell Biol. 13 (5): 505–14. PMID 8024693.
- Cui L, Yu WP, DeAizpurua HJ, et al. (1996). "Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes". J. Biol. Chem. 271 (40): 24817–23. PMID 8798755.
- Kawasaki E, Hutton JC, Eisenbarth GS (1996). "Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes". Biochem. Biophys. Res. Commun. 227 (2): 440–7. PMID 8878534.
- Schmidli RS, Colman PG, Cui L, et al. (1998). "Antibodies to the protein tyrosine phosphatases IAR and IA-2 are associated with progression to insulin-dependent diabetes (IDDM) in first-degree relatives at-risk for IDDM". Autoimmunity. 28 (1): 15–23. PMID 9754810.
- van den Maagdenberg AM, Schepens JT, Schepens MT, et al. (1999). "Assignment of Ptprn2, the gene encoding receptor-type protein tyrosine phosphatase IA-2beta, a major autoantigen in insulin-dependent diabetes mellitus, to mouse chromosome region 12F". Cytogenet. Cell Genet. 82 (3–4): 153–5. S2CID 46872092.
- Berghs S, Aggujaro D, Dirkx R, et al. (2001). "betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system". J. Cell Biol. 151 (5): 985–1002. PMID 11086001.
- Kubosaki A, Gross S, Miura J, et al. (2004). "Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice". Diabetes. 53 (7): 1684–91. PMID 15220191.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. S2CID 13709685.
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