TPTE

Putative tyrosine-protein phosphatase TPTE is an enzyme that in humans is encoded by the TPTE gene.^[3][4]

Function

TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.^[4] TPTE is a primate-specific duplicate of the TPTE2 (TPIP) inositol phospholipid phosphatase;^[5] TPTE itself is predicted to lack phosphatase activity.^[6] TPTE and TPTE2 are the mammalian homologues to the subfamily of voltage sensitive phosphatases.

References

Further reading

• Antonarakis SE (1998). "10 years of Genomics, chromosome 21, and Down syndrome". Genomics. 51 (1): 1–16.
  PMID 9693027
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• Chen H, Rossier C, Morris MA, et al. (2000). "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y.". Hum. Genet. 105 (5): 399–409.
  PMID 10598804
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• Guipponi M, Yaspo ML, Riesselman L, et al. (2000). "Genomic structure of a copy of the human TPTE gene which encompasses 87 kb on the short arm of chromosome 21" (PDF). Hum. Genet. 107 (2): 127–31.
  S2CID 29304641
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• Wu Y, Dowbenko D, Pisabarro MT, et al. (2001). "PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase". J. Biol. Chem. 276 (24): 21745–53.
  PMID 11279206
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• Guipponi M, Tapparel C, Jousson O, et al. (2002). "The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family" (PDF). Hum. Genet. 109 (6): 569–75.
  S2CID 8267495
  .

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