Phosphoenolpyruvic acid

In glycolysis

In gluconeogenesis

Interactive pathway map

In plants

References

Phosphoenolpyruvic acid
Names
	Preferred IUPAC name 2-(Phosphonooxy)prop-2-enoic acid
	Other names Phosphoenolpyruvic acid, PEP
Identifiers
CAS Number	138-08-9 ;
3D model ( JSmol)	Interactive image;
ChEBI	CHEBI:44897 ;
ChemSpider	980 ;
DrugBank	DB01819 ;
ECHA InfoCard	100.004.830
IUPHAR/BPS	4692;
KEGG	C00074 ;
PubChem CID	1005;
UNII	545YL308OW ;
CompTox Dashboard (EPA)	DTXSID80861797 ;
	InChI InChI=1S/C3H5O6P/c1-2(3(4)5)9-10(6,7)8/h1H2,(H,4,5)(H2,6,7,8) Key: DTBNBXWJWCWCIK-UHFFFAOYSA-N ;
	SMILES O=C(O)C(OP(=O)(O)O)=C;
Properties
Chemical formula	C3H5O6P
Molar mass	168.042
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Phosphoenolpyruvate (2-phosphoenolpyruvate, PEP) is the

phosphotransferase system.^[1]^[2]

PEP is formed by the action of the

2-phosphoglyceric acid. Metabolism of PEP to pyruvic acid by pyruvate kinase (PK) generates adenosine triphosphate (ATP) via substrate-level phosphorylation. ATP is one of the major currencies of chemical energy within cells

.

Compound C00631 at KEGG Pathway Database. Enzyme 4.2.1.11 at KEGG Pathway Database. Compound C00074 at KEGG Pathway Database. Enzyme 2.7.1.40 at KEGG Pathway Database. Compound C00022 at KEGG Pathway Database.

PEP is formed from the

rate-limiting step in gluconeogenesis:^[3]

GTP + oxaloacetate → GDP + phosphoenolpyruvate + CO₂

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

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|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

PEP may be used for the synthesis of

3-deoxy-D-arabinoheptulosonate-7-phosphate (DAHP), in a reaction catalyzed by the enzyme DAHP synthase

.

In addition, in

carbon fixation. The chemical equation, as catalyzed by phosphoenolpyruvate carboxylase

(PEP carboxylase), is:

PEP + HCO−3 → oxaloacetate

2-phospho-D-glycerate

phosphoenolpyruvate

Pyruvate kinase

ISBN 0-7167-3051-0
.

ISBN 1-57259-153-6
.

^ "InterPro: IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising". Retrieved 2007-08-17.

^ "BioCarta - Charting Pathways of Life". Retrieved 2007-08-17.

v
t
e
Glycolysis metabolic pathway

Glucose

Hexokinase

ATP

ADP

Glucose 6-phosphate

Glucose-6-phosphate
isomerase

Fructose 6-phosphate

Phosphofructokinase-1

ATP

ADP

Fructose 1,6-bisphosphate

Fructose-bisphosphate
aldolase

Dihydroxyacetone phosphate

+

+

Glyceraldehyde 3-phosphate

Triosephosphate
isomerase

2 × Glyceraldehyde 3-phosphate

2 ×

Glyceraldehyde-3-phosphate
dehydrogenase

NAD⁺+ P_i

NADH + H⁺

NAD⁺+ P_i

NADH + H⁺

2 ×
1,3-Bisphosphoglycerate

2 ×

Phosphoglycerate kinase

ADP

ATP

ADP

ATP

2 × 3-Phosphoglycerate

2 ×

Phosphoglycerate mutase

2 × 2-Phosphoglycerate

2 ×

Phosphopyruvate
hydratase (enolase
)

H₂O

H₂O

2 ×
Phosphoenolpyruvate

2 ×

Pyruvate kinase

ADP

ATP

2 × Pyruvate

2 ×

Retrieved from "https://en.wikipedia.org/w/index.php?title=Phosphoenolpyruvic_acid&oldid=1213214484"

[WikiPathways-4] The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

[1] ISBN 0-7167-3051-0
.

[2] ISBN 1-57259-153-6
.

[3] "InterPro: IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising". Retrieved 2007-08-17.

[5] "BioCarta - Charting Pathways of Life". Retrieved 2007-08-17.

[1]

[2]

[3]