Radotinib
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Trade names | Supect |
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Radotinib (
INN; trade name Supect), and sometimes referred to by its investigational name IY5511, is a drug for the treatment of different types of cancer, most notably Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML)[1] with resistance or intolerance of other Bcr-Abl tyrosine-kinase inhibitors, such as patients resistant or intolerant to imatinib
.
Radotinib is being developed by Ilyang Pharmaceutical Co., Ltd of South Korea[2] and is co-marketed by Daewoong Pharmaceutical Co. Ltd, in South Korea.[3] Radotinib completed a multi-national Phase II clinical trial study in 2012[4] and in August 2011, Ilyang initiated a Phase III, multinational, multi-center, open-label, randomized study for first-line indication.[5] Its mechanism of action involves inhibition of the Bcr-Abl tyrosine kinase and of platelet-derived growth factor receptor (PDGFR).[6]
References
- ISBN 9780124171503.
- ^ "Il-Yang Pharmaceutical".
- ^ Yoon EK (23 October 2012). "Daewoong will market Ilyang's new leukemia drug". Daily Pharm News. Archived from the original on 2016-03-03.
- PMID 24705186.
- ^ Clinical trial number NCT01511289 for "A Phase 3 Multinational, Multi-center, Open-Label, Randomized Study of the Efficacy of Radotinib Versus Imatinib in Newly Diagnosed Ph+ CML Patients in Early Chronic Phase" at ClinicalTrials.gov
- ^ "Radotinib hydrochloride". NCI Drug Dictionary. National Cancer Institute. 2011-02-02.