Crizotinib

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Crizotinib
Clinical data
Trade namesXalkori, others
Other namesPF-02341066
1066
AHFS/Drugs.comMonograph
MedlinePlusa612018
License data
Pregnancy
category
  • AU: D
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability43%
Protein binding91%
MetabolismLiver (CYP3A4/CYP3A5-mediated)
Elimination half-life42 hours
ExcretionFaeces (63%), urine (22%)
Identifiers
  • 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
JSmol)
  • C1(=C(C=CC(=C1[C@H](OC2=C(N=CC(=C2)C3=C[N](N=C3)C4CCNCC4)N)C)Cl)F)Cl
  • InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 checkY
  • Key:KTEIFNKAUNYNJU-GFCCVEGCSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Crizotinib, sold under the brand name Xalkori among others, is an

c-ros oncogene 1) inhibitor.[6][7][8]

Medical uses

Crizotinib is

indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) or relapsed or refractory, systemic anaplastic large cell lymphoma (ALCL) that is ALK-positive.[2][3]

It is also indicated for the treatment of unresectable, recurrent, or refractory inflammatory anaplastic lymphoma kinase (ALK)-positive myofibroblastic tumors (IMT).[2][9]

Mechanism of action

Human anaplastic lymphoma kinase in complex with crizotinib. PDB 2xp2[10]

Crizotinib has an

K-Ras gene.[11][12] The number of new cases of ALK-fusion NSLC is about 9,000 per year in the U.S. and about 45,000 worldwide.[13][14]

ALK mutations are thought to be important in driving the malignant phenotype in about 15% of cases of neuroblastoma, a rare form of peripheral nervous system cancer that occurs almost exclusively in very young children.[15]

Crizotinib inhibits the

neoplasms.[16]

Crizotinib is thought to exert its effects through modulation of the growth, migration, and invasion of malignant cells.[16][17] Other studies suggest that crizotinib might also act via inhibition of angiogenesis in malignant tumors.[18]

Society and culture

Legal status

In August 2011, the US Food and Drug Administration (FDA) approved crizotinib to treat certain late-stage (locally advanced or metastatic) non-small cell lung cancers that express the abnormal anaplastic lymphoma kinase (ALK) gene.[4] Approval required a companion molecular test for the EML4-ALK fusion. In March 2016, the FDA approved crizotinib in ROS1-positive non-small cell lung cancer.[19]

In October 2012, the European Medicines Agency (EMA) approved the use of crizotinib to treat non-small cell lung cancers that express the abnormal anaplastic lymphoma kinase (ALK) gene.[3][20]

Research

Lung cancer

Crizotinib caused tumors to shrink or stabilize in 90% of 82 patients carrying the ALK fusion gene.[12][13] Tumors shrank at least 30% in 57% of people treated.[13] [21] Most had adenocarcinoma, and had never smoked or were former smokers.[12] They had undergone treatment with an average of three other drugs prior to receiving crizotinib, and only 10% were expected to respond to standard therapy.[12][22] They were given 250 mg crizotinib twice daily for a median duration of six months.[12] Approximately 50% of these patients had at least one side effect, such as nausea, vomiting, or diarrhea.[22] Some responses to crizotinib have lasted up to 15 months.[22]

A Phase III trial, PROFILE 1007,

taxotere) in the treatment of ALK-positive NSCLC.[24][14][25] Additionally, a phase 2 trial, PROFILE 1005, studies patients meeting similar criteria who have received more than one line of prior chemotherapy.[14]

In February 2016, the J-ALEX phase III study comparing alectinib with crizotinib ALK-positive metastatic NSCLC was terminated early because an interim analysis showed that progression-free survival was longer with alectinib.[26] These results were confirmed in a 2017 analysis.[27]

Lymphomas

In people affected by relapsed or refractory ALK+ anaplastic large cell lymphoma, crizotinib produced objective response rates ranging from 65% to 90% and 3 year progression free survival rates of 60–75%. No relapse of the lymphoma was ever observed after the initial 100 days of treatment. Treatment must be continued indefinitely at present.[28][29][30]

Other cancers

Crizotinib is also being tested in clinical trials of advanced disseminated neuroblastoma.[31]

References

  1. ^ "Prescription medicines and biologicals: TGA annual summary 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 31 March 2024.
  2. ^ a b c d "Xalkori- crizotinib capsule". DailyMed. Archived from the original on 9 October 2021. Retrieved 18 April 2021.
  3. ^ a b c d "Xalkori EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 19 April 2021. Retrieved 18 April 2021.
  4. ^ a b "Drug Approval Package: Xalkori Capsules (crizotinib) NDA #202570". U.S. Food and Drug Administration (FDA). 27 September 2011. Archived from the original on 7 April 2021. Retrieved 18 April 2021.
  5. ^ "Summary Review for Regulatory Action" (PDF). U.S. Food and Drug Administration (FDA). 26 August 2011. Archived (PDF) from the original on 6 April 2021. Retrieved 19 April 2021.
  6. S2CID 23715951
    .
  7. PMID 23671386
    .
  8. PMID 24455567
    .
  9. ^ "FDA approves crizotinib for ALK-positive inflammatory myofibroblastic tumor". U.S. Food and Drug Administration (FDA) (Press release). 14 July 2022. Archived from the original on 14 July 2022. Retrieved 14 July 2022. Public Domain This article incorporates text from this source, which is in the public domain.
  10. PMID 21812414
    .
  11. ^ a b c "Maintenance Therapy for Non-Small Cell Lung Cancer". MedscapeCME. 12 May 2010. Archived from the original on 6 December 2012. Retrieved 7 June 2010.
  12. ^ a b c d e "ALK inhibitor crizotinib has high response rate in patients with ALK-positive NSCLC". HemOncToday. 5 June 2010. Archived from the original on 6 April 2020. Retrieved 7 June 2010.
  13. ^ a b c Winslow R (7 June 2010). "Advances Come in War on Cancer". The Wall Street Journal. Archived from the original on 9 October 2021. Retrieved 7 June 2010.
  14. ^ a b c "Pfizer Oncology To Present New Clinical Data From Ten Molecules Across Multiple Tumor Types" (PDF) (Press release). Pfizer Oncology. 20 May 2010. Archived from the original (PDF) on 12 June 2010. Retrieved 7 June 2010.
  15. PMID 20101209
    .
  16. ^ a b Clinical trial number NCT00585195 for "A Study Of Oral PF-02341066, A c-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer" at ClinicalTrials.gov
  17. PMID 18089725
    .
  18. PMID 17483355
    .
  19. ^ "NICE backs Pfizer's Xalkori after squeezing out a new discount – FiercePharma". 18 August 2016. Archived from the original on 8 August 2020. Retrieved 18 August 2016.
  20. ^ "Xalkori - EMEA/H/C/002489 - T/0059" (PDF). European Medicines Agency. 2012. Archived (PDF) from the original on 4 October 2018. Retrieved 22 October 2018.
  21. ^ Helwick (2010). "Novel Agent Demonstrates Striking Activity in ALK-positive NSCLC". Archived from the original on 28 January 2011. NB Fig 1.
  22. ^ a b c "Gene-based lung cancer drug shows promise". NBC News. 7 May 2010. Retrieved 7 June 2010.
  23. ^ "Crizotinib Clinical Trials – Currently Ongoing and/or Enrolling" (PDF). Fact Sheet. Pfizer. Archived (PDF) from the original on 3 March 2016. Retrieved 16 August 2014.
  24. ^ Clinical trial number NCT00932451 for "An Investigational Drug, PF-02341066, Is Being Studied In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene" at ClinicalTrials.gov
  25. ^ Clinical trial number NCT00932893 for "An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene" at ClinicalTrials.gov
  26. ^ "Chugai's ALK Inhibitor "Alecensa" Trial Stopped Early for Benefit" (PDF). Roche. February 2016. Archived (PDF) from the original on 18 April 2016. Retrieved 8 December 2017.
  27. ^ "FDA approves Alecensa for ALK-positive metastatic non-small cell lung cancer". Healio. November 2017. Archived from the original on 9 December 2017. Retrieved 8 December 2017.
  28. ^ Gambacorti-Passerini C, et al. (2010). "Clinical Activity of Crizotinib In Advanced, Chemoresistant ALK+ Lymphoma Patients". Annual Meeting of the American Society of Hematology. Orlando, Florida.
  29. PMID 21345110
    .
  30. PMID 24491302
    .
  31. doi:10.1200/jco.2009.27.15_suppl.10008b. Archived from the original
    on 16 August 2014.

External links

  • "Crizotinib". NCI Drug Dictionary. National Cancer Institute.
  • "Crizotinib". National Cancer Institute.
  • Clinical trial number NCT00585195 for "A Study Of Oral PF-02341066, A C-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer (PROFILE 1001)" at ClinicalTrials.gov
  • Clinical trial number NCT00932893 for "An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene" at ClinicalTrials.gov
  • Clinical trial number NCT00939770 for "Crizotinib in Treating Younger Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma" at ClinicalTrials.gov
  • Clinical trial number NCT01154140 for "A Clinical Trial Testing The Efficacy Of Crizotinib Versus Standard Chemotherapy Pemetrexed Plus Cisplatin Or Carboplatin In Patients With ALK Positive Non Squamous Cancer Of The Lung (PROFILE 1014)" at ClinicalTrials.gov
  • Clinical trial number NCT01979536 for "Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma" at ClinicalTrials.gov
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