Sterol 24-C-methyltransferase
| sterol 24-C-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
 | This article includes a list of general references, but it lacks sufficient corresponding inline citations. (October 2021) |
In
enzymology, a sterol 24-C-methyltransferase (EC 2.1.1.41) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol
Thus, the two
S-adenosylhomocysteine and 24-methylene-5alpha-cholest-8-en-3beta-ol
.
This enzyme belongs to the family of
biosynthesis of steroids. It employs one cofactor, glutathione
.
References
- Moore JT, Gaylor JL (1969). "Isolation and purification of an S-adenosylmethionine: delta 24-sterol methyltransferase from yeast". J. Biol. Chem. 244 (23): 6334–40. PMID 5354959.
- Venkatramesh M, Guo DA, Jia Z, Nes WD (1996). "Mechanism and structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase from Saccharomyces cerevisiae". Biochim. Biophys. Acta. 1299 (3): 313–24. PMID 8597586.
- MD, Zhou W, Lopez M, Nes WD (1997). ", Stereochemical features of C-methylation on the path to Delta24(28)-methylene and Delta24(28)-ethylidene sterols: studies on the recombinant phytosterol methyl transferase from Arabidopsis thaliana". Tetrahedron Lett. 38 (35): 6115–6118. .
- Bouvier-Nave P, Husselstein T, Benveniste P (1998). "Two families of sterol methyltransferases are involved in the first and the second methylation steps of plant sterol biosynthesis". Eur. J. Biochem. 256 (1): 88–96. PMID 9746350.
- Nes WD, McCourt BS, Zhou WX, Ma J, Marshall JA, Peek LA, Brennan M (1998). "Overexpression, purification, and stereochemical studies of the recombinant (S)-adenosyl-L-methionine: delta 24(25)- to delta 24(28)-sterol methyl transferase enzyme from Saccharomyces cerevisiae". Arch. Biochem. Biophys. 353 (2): 297–311. PMID 9606964.
