Synergy
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Synergy is an interaction or cooperation giving rise to a whole that is greater than the simple sum of its parts (i.e., a non-linear addition of force, energy, or effect).[1] The term synergy comes from the Attic Greek word συνεργία synergia[2] from synergos, συνεργός, meaning "working together". Synergy is similar in concept to emergence.
History
The words synergy and synergetic have been used in the field of physiology since at least the middle of the 19th century:
SYN'ERGY, Synergi'a, Synenergi'a, (F.) Synergie; from συν, 'with', and εργον, 'work'. A correlation or concourse of action between different organs in health; and, according to some, in disease.
- —Dunglison, Robley Medical Lexicon Blanchard and Lea, 1853
In 1896, Henri Mazel applied the term "synergy" to social psychology by writing La synergie sociale, in which he argued that Darwinian theory failed to account of "social synergy" or "social love", a collective evolutionary drive. The highest civilizations were the work not only of the elite but of the masses too; those masses must be led, however, because the crowd, a feminine and unconscious force, cannot distinguish between good and evil.[3]
In 1909, Lester Frank Ward defined synergy as the universal constructive principle of nature:
I have characterized the social struggle as centrifugal and social solidarity as centripetal. Either alone is productive of evil consequences. Struggle is essentially destructive of the social order, while communism removes individual initiative. The one leads to disorder, the other to degeneracy. What is not seen—the truth that has no expounders—is that the wholesome, constructive movement consists in the properly ordered combination and interaction of both these principles. This is social synergy, which is a form of cosmic synergy, the universal constructive principle of nature.
- —Ward, Lester F. Glimpses of the Cosmos, volume VI (1897–1912) G. P. Putnam's Sons, 1918, p. 358
In Christian theology, synergism is the idea that salvation involves some form of cooperation between divine grace and human freedom.
A modern view of synergy in natural sciences derives from the relationship between energy and information. Synergy is manifested when the system makes the transition between the different information (i.e. order, complexity) embedded in both systems.[4]
Abraham Maslow and John Honigmann drew attention to an important development in the cultural anthropology field which arose in lectures by Ruth Benedict from 1941, for which the original manuscripts have been lost but the ideas preserved in "Synergy: Some Notes of Ruth Benedict" (1969).
Descriptions and usages
In the natural world, synergistic phenomena are ubiquitous, ranging from
In the context of organizational behavior, following the view that a cohesive group is more than the sum of its parts, synergy is the ability of a group to outperform even its best individual member. These conclusions are derived from the studies conducted by Jay Hall on a number of laboratory-based group ranking and prediction tasks. He found that effective groups actively looked for the points in which they disagreed and in consequence encouraged conflicts amongst the participants in the early stages of the discussion. In contrast, the ineffective groups felt a need to establish a common view quickly, used simple decision making methods such as averaging, and focused on completing the task rather than on finding solutions they could agree on.[7]: 276 In a technical context, its meaning is a construct or collection of different elements working together to produce results not obtainable by any of the elements alone. The elements, or parts, can include people, hardware, software, facilities, policies, documents: all things required to produce system-level results. The value added by the system as a whole, beyond that contributed independently by the parts, is created primarily by the relationship among the parts, that is, how they are interconnected. In essence, a system constitutes a set of interrelated components working together with a common objective: fulfilling some designated need.[8]
If used in a business application, synergy means that teamwork will produce an overall better result than if each person within the group were working toward the same goal individually. However, the concept of group
There are negative aspects of group cohesion that have an effect on group decision-making and hence on group effectiveness. There are two issues arising. The
A second, potential negative consequence of group cohesion is group think. Group think is a mode of thinking that people engage in when they are deeply involved in cohesive group, when the members' striving for unanimity overrides their motivation to appraise realistically the alternative courses of action. Studying the events of several American policy "disasters" such as the failure to anticipate the Japanese attack on Pearl Harbor (1941) and the Bay of Pigs Invasion fiasco (1961), Irving Janis argued that they were due to the cohesive nature of the committees that made the relevant decisions.[7]: 283
That decisions made by committees lead to failure in a simple system is noted by Dr. Chris Elliot. His case study looked at
The idea of a systemic approach is endorsed by the United Kingdom Health and Safety Executive. The successful performance of the health and safety management depends upon the analyzing the causes of incidents and accidents and learning correct lessons from them. The idea is that all events (not just those causing injuries) represent failures in control, and present an opportunity for learning and improvement.[10] UK Health and Safety Executive, Successful health and safety management (1997): this book describes the principles and management practices, which provide the basis of effective health and safety management. It sets out the issues that need to be addressed, and can be used for developing improvement programs, self-audit, or self-assessment. Its message is that organizations must manage health and safety with the same degree of expertise and to the same standards as other core business activities, if they are to effectively control risks and prevent harm to people.
The term synergy was refined by
- A dynamic state in which combined action is favored over the difference of individual component actions.
- Behavior of whole systems unpredicted by the behavior of their parts taken separately, known as emergent behavior.
- The cooperative action of two or more stimuli (or drugs), resulting in a different or greater response than that of the individual stimuli.
Information theory
Mathematical formalizations of synergy have been proposed using information theory to rigorously define the relationships between "wholes" and "parts".[12] In this context, synergy is said to occur when there is information present in the joint state of multiple variables that cannot be extracted from the individual parts considered individually. For example, consider the logical XOR gate. If for three binary variables, the mutual information between any individual source and the target is 0 bit. However, the joint mutual information bit. There is information about the target that can only be extracted from the joint state of the inputs considered jointly, and not any others.
There is, thus far, no universal agreement on how synergy can best be quantified, with different approaches that decompose information into redundant, unique, and synergistic components appearing in the literature.[13][14][15][16] Despite the lack of universal agreement, information-theoretic approaches to statistical synergy have been applied to diverse fields, including climatology,[17] neuroscience[18][19][20] sociology,[21] and machine learning[22] Synergy has also been proposed as a possible foundation on which to build a mathematically robust definition of emergence in complex systems[23][24] and may be relevant to formal theories of consciousness.[25]
Biological sciences
Synergy of various kinds has been advanced by Peter Corning as a causal agency that can explain the progressive evolution of complexity in living systems over the course of time. According to the Synergism Hypothesis, synergistic effects have been the drivers of cooperative relationships of all kinds and at all levels in living systems. The thesis, in a nutshell, is that synergistic effects have often provided functional advantages (economic benefits) in relation to survival and reproduction that have been favored by natural selection. The cooperating parts, elements, or individuals become, in effect, functional "units" of selection in evolutionary change.[26][27][28] Similarly, environmental systems may react in a non-linear way to perturbations, such as climate change, so that the outcome may be greater than the sum of the individual component alterations. Synergistic responses are a complicating factor in environmental modeling.[29]
Pest synergy
Pest synergy would occur in a
Drug synergy
Mechanisms that may be involved in the development of synergistic effects include:
- Effect on the same cellular system (e.g. two different antibiotics like a penicillin and an aminoglycoside; penicillins damage the cell wall of gram-positive bacteria and improve the penetration of aminoglycosides).[30]: 698
- Bioavailability (e.g. ayahuasca (or pharmahuasca) consists of DMT combined with MAOIs that interfere with the action of the MAO enzyme and stop the breakdown of chemical compounds such as DMT).
- Reduced risk for attached to dextroamphetamine, may have a lower liability for abuse as a recreational drug)
- Increased potency (e.g. as with other NSAIDs, combinations of aspirin and caffeine provide slightly greater pain relief than aspirin alone.[31]).
- Prevention or delay of degradation in the body (e.g. the antibiotic Ciprofloxacin inhibits the metabolism of Theophylline).[30]: 931
- Slowdown of excretion (e.g. renal excretion of Penicillin and thus prolongs its effect).[30]: 931
- Anticounteractive action: for example, the effect of topoisomerase 1, consequently the cytostatic effect is increased.[32]
- Effect on the same receptor but different sites (e.g. the coadministration of benzodiazepines and barbiturates, both act by enhancing the action of GABA on GABAA receptors, but benzodiazepines increase the frequency of channel opening, whilst barbiturates increase the channel closing time, making these two drugs dramatically enhance GABAergic neurotransmission).[citation needed]
- In addition to the chemical nature of the drug itself, the topology of the chemical reaction network that connect the two targets determines the type of drug-drug interaction.[33]
More mechanisms are described in an exhaustive 2009 review.[32]
Toxicological synergy
Toxicological synergy is of concern to the public and regulatory agencies because chemicals individually considered safe might pose unacceptable health or ecological risk in combination. Articles in scientific and lay journals include many definitions of chemical or toxicological synergy, often vague or in conflict with each other. Because toxic interactions are defined relative to the expectation under "no interaction", a determination of synergy (or antagonism) depends on what is meant by "no interaction".[34] The United States Environmental Protection Agency has one of the more detailed and precise definitions of toxic interaction, designed to facilitate risk assessment.[35] In their guidance documents, the no-interaction default assumption is dose addition, so synergy means a mixture response that exceeds that predicted from dose addition. The EPA emphasizes that synergy does not always make a mixture dangerous, nor does antagonism always make the mixture safe; each depends on the predicted risk under dose addition.
For example, a consequence of pesticide use is the risk of health effects. During the registration of pesticides in the United States exhaustive tests are performed to discern health effects on humans at various exposure levels. A regulatory upper limit of presence in foods is then placed on this pesticide. As long as residues in the food stay below this regulatory level, health effects are deemed highly unlikely and the food is considered safe to consume.
However, in normal agricultural practice, it is rare to use only a single pesticide. During the production of a crop, several different materials may be used. Each of them has had determined a regulatory level at which they would be considered individually safe. In many cases, a commercial pesticide is itself a combination of several chemical agents, and thus the safe levels actually represent levels of the mixture. In contrast, a combination created by the end user, such as a farmer, has rarely been tested in that combination. The potential for synergy is then unknown or estimated from data on similar combinations. This lack of information also applies to many of the chemical combinations to which humans are exposed, including residues in food, indoor air contaminants, and occupational exposures to chemicals. Some groups think that the rising rates of cancer, asthma, and other health problems may be caused by these combination exposures; others have alternative explanations. This question will likely be answered only after years of exposure by the population in general and research on chemical toxicity, usually performed on animals. Examples of pesticide synergists include
Human synergy
Synergy exists in individual and social interactions among humans, with some arguing that social cooperation requires synergy to continue.[37] One way of quantifying synergy in human social groups is via energy use, where larger groups of humans (i.e., cities) use energy more efficiently that smaller groups of humans.[1]
Human synergy can also occur on a smaller scale, like when individuals huddle together for warmth or in workplaces where labor specialization increase efficiencies.[38]
When synergy occurs in the work place, the individuals involved get to work in a positive and supportive working environment. When individuals get to work in environments such as these, the company reaps the benefits. The authors of Creating the Best Workplace on Earth Rob Goffee and Gareth Jones, state that "highly engaged employees are, on average, 50% more likely to exceed expectations that the least-engaged workers. And companies with highly engaged people outperform firms with the most disengaged folks- by 54% in employee retention, by 89% in customer satisfaction, and by fourfold in revenue growth.[39]: 100 Also, those that are able to be open about their views on the company, and have confidence that they will be heard, are likely to be a more organized employee who helps his/ her fellow team members succeed.[39]
Human interaction with technology can also increase synergy. Organismic computing is an approach to improving group efficacy by increasing synergy in human groups via technological means.