Terpin
Clinical data | |
---|---|
Other names | Dipenteneglycol, p-menthane-1,8-diol |
ATC code |
|
Identifiers | |
| |
JSmol) | |
| |
|
Terpin, used as the hydrate (terpin·H2O), is an expectorant, used to loosen mucus in patients with bronchitis and related conditions. It is derived from sources such as turpentine, oregano, thyme, and eucalyptus. It was used in the United States in the late nineteenth century, but was removed from marketed medications in the 1990s after the Food and Drug Administration (FDA) found a lack of evidence of safety and effectiveness.[1] Elixirs of terpin hydrate are still available with a prescription, but must be prepared by a compounding pharmacy.
It can be prepared from other volatile oils like geraniol and linalool by adding dilute acids (5% sulfuric acid) to them.[citation needed]
Medical uses
Terpin hydrate is an expectorant, used in the treatment of acute and chronic
Adverse effects
Adverse reactions include depression of the respiration, sedation, coordination disorders, constipation, and urinary retention.
Long-term administration of the combination product of terpin hydrate with codeine may lead to codeine dependence. Terpin hydrate with codeine is often mixed with alcohol as codeine is not as readily as soluble in water. The high alcohol content (42 percent) may increase depression of the central nervous system, codeine metabolism, as well as abuse potential.[citation needed]
Mechanism of action
A
History
Terpin hydrate was first
The following preparations of terpin hydrate were available in the United States in 1907:[3]
Currently available expectorants in the United States
Currently,
References
- ^ a b United States Food and Drug Administration: Code of Federal Regulations, Title 21, Volume 5, April 1, 2009
- ^ Codeine with Terpin hydrate Archived 2010-11-20 at the Wayback Machine
- ^ a b Drug Store Museum: Terpin Hydrate Archived 2011-01-14 at the Wayback Machine