Arotinolol

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Arotinolol
Clinical data
Trade namesAlmarl
Other namesS-596
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral (tablets)
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability2 hours
Elimination half-life10 hours
Identifiers
  • (RS)-5-(2-{[3-(tert-butylamino)-2-hydroxypropyl]sulfanyl}- 1,3-thiazol-4-yl)thiophene-2-carboxamide
JSmol)
  • CC(C)(C)NCC(CSC1=NC(=CS1)C2=CC=C(S2)C(=O)N)O
  • InChI=1S/C15H21N3O2S3/c1-15(2,3)17-6-9(19)7-21-14-18-10(8-22-14)11-4-5-12(23-11)13(16)20/h4-5,8-9,17,19H,6-7H2,1-3H3,(H2,16,20) checkY
  • Key:BHIAIPWSVYSKJS-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Arotinolol (

INN, marketed under the tradename Almarl) is a medication in the class of mixed alpha/beta blockers.[1] It also acts as a β3 receptor agonist.[2] A 1979 publication suggests arotinolol as having first been described in the scientific literature by Sumitomo Chemical as "β-adrenergic blocking, antiarrhythmic compound S-596".[3]

Medical uses

It is used in the treatment of high blood pressure[4] and essential tremor.[5][6] Recommended dosage is 10 to 30 mg per day.[citation needed]

References

  1. PMID 11478592.Closed access icon
  2. PMID 1383578
    .
  3. ISSN 1347-8397.Open access icon
  4. PMID 11675958.Open access icon
  5. PMID 12853233.Closed access icon
  6. ^ "Almarl (アルマール) Arotinolol HCl Tablets. Full Prescribing Information" (PDF). Sumitomo Dainippon Pharma Co., Ltd. Archived from the original (PDF) on 7 May 2012. Retrieved 6 March 2016.

External links

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