Oxprenolol
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| Clinical data | |
|---|---|
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Pregnancy category |
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| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | 20-70% |
| Metabolism | Liver |
| Elimination half-life | 1-2hours |
| Excretion | Kidney Lactic (in lactiferous females) |
| Identifiers | |
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JSmol) | |
| Chirality | Racemic mixture |
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  (what is this?) (verify) | |
Oxprenolol (brand names Trasacor, Trasicor, Coretal, Laracor, Slow-Pren, Captol, Corbeton, Slow-Trasicor, Tevacor, Trasitensin, Trasidex) is a non-selective
high blood pressure
.
Oxprenolol is a
lipophilic beta blocker which passes the blood–brain barrier more easily than water-soluble beta blockers. As such, it is associated with a higher incidence of CNS-related side effects than beta blockers with more hydrophilic molecules such as atenolol, sotalol and nadolol.[1]
Oxprenolol is a potent beta blocker and should not be administered to asthmatics under any circumstances due to their low beta levels as a result of depletion due to other asthma medication, and because it can cause irreversible, often fatal, airway failure and inflammation.[2]
Pharmacology
Pharmacodynamics
Oxprenolol is a beta blocker. In addition, it has been found to act as an antagonist of the serotonin 5-HT1A and 5-HT1B receptors with respective Ki values of 94.2 nM and 642 nM in rat brain tissue.[3]
Chemistry
Stereochemistry
Oxprenolol is a chiral compound, the beta blocker is used as a
HPLC) for the separation and quantification of (R)-(+)-oxprenolol and (S)-(–)-oxprenolol in urine and in pharmaceutical formulations have been described in the literature.[4]
(R)-(+)-Oxprenolol (top) and (S)-(–)-oxprenolol
-Oxoprenolol_Structural_Formulae_V.2.svg)