Azacosterol

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Azacosterol
Ball-and-stick model of azacosterol
Clinical data
Other names20,25-Diazacholesterol; 20,25-Azacholesterol; Azasterol; Diazasterol; SC-12937; DAC; IMD-760; 17β-(3-(Dimethylamino)propyl)methyl-
amino)androst-5-en-3β-ol
Routes of
administration		By mouth
Identifiers
  • (3S,8R,9S,10R,13S,14S,17S)-17-[3-(dimethylamino)propyl-methylamino]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
JSmol)
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2N(C)CCCN(C)C)CC=C4[C@@]3(CC[C@@H](C4)O)C
  • InChI=1S/C25H44N2O/c1-24-13-11-19(28)17-18(24)7-8-20-21-9-10-23(25(21,2)14-12-22(20)24)27(5)16-6-15-26(3)4/h7,19-23,28H,6,8-17H2,1-5H3/t19-,20-,21-,22-,23-,24-,25-/m0/s1 checkY
  • Key:FMTFZYKYVZBISL-HUVRVWIJSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Azacosterol (

derivative of cholesterol in which two carbon atoms have been replaced with nitrogen atoms.[5]

Azacosterol acts as an

antifertility effects of the drug in birds are mediated by inhibition of steroid hormone production, steroid hormones being synthesized from cholesterol.[4] Due to prevention of the metabolism of desmosterol, the drug causes it to accumulate, in turn producing side effects such as hyperkeratosis, particularly of the palms and soles.[6]

See also

References

  1. ISBN 978-1-4757-2085-3
    .
  2. ISBN 978-0-7514-0499-9
    .
  3. ISBN 978-0-8155-1856-3
    .
  4. ^
    PMID 95596
    .
  5. PMID 14056455
    .
  6. ^
    ISBN 978-1-4832-1545-7
    .


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