Carfenazine
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Other names | Proketazine, Carphenazin |
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Routes of administration | Oral |
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Carfenazine (
Synthesis
The alkylation reaction between 2-Propionyl Phenothiazine [92-33-1] (1) and 1-Bromo-3-chloropropane (2) gives 1-[10-(3-chloropropyl)phenothiazin-2-yl]propan-1-one [95157-45-2] (3). A second alkylation step, this time with 2-(1-Piperazinyl)ethanol [103-76-4] (4) completes the synthesis of Carfenazine (5).
NB: Although above procedure is proof-of-concept, bear in mind no protecting group {Other patent uses ketalization technique}
Analogues
- propanoylgroup.
- trifluoromethyl on position 2 of the phenothiazinering.
References
- ISBN 978-1-4757-2085-3.
- ISBN 978-0-8155-1856-3.
- ISBN 978-1-60831-708-0.
- ^ Zhuraulev, S.V. et al, Zh. Obshch. Khim., 1962, 32, 2244
- ^ M. H. Sherlock, N. Sperber, U.S. patent 2,985,654 (1961 to Schering)
- American Home Products).